Liver Failure/Cirrhosis/Portal Hypertension
Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis †
Article first published online: 7 APR 2011
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 53, Issue 4, pages 1306–1315, April 2011
How to Cite
Zhang, D., Utsumi, T., Huang, H.-C., Gao, L., Sangwung, P., Chung, C., Shibao, K., Okamoto, K., Yamaguchi, K., Groszmann, R. J., Jozsef, L., Hao, Z., Sessa, W. C. and Iwakiri, Y. (2011), Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis . Hepatology, 53: 1306–1315. doi: 10.1002/hep.24200
Potential conflict of interest: Nothing to report.
- Issue published online: 7 APR 2011
- Article first published online: 7 APR 2011
- Accepted manuscript online: 19 JAN 2011 09:02AM EST
- Manuscript Received: 6 DEC 2010
- Manuscript Accepted: 5 JAN 2010
- National Institute of Diabetes and Digestive and Kidney Disorders. Grant Numbers: R01DK082600, K01DK067933
- Yale Liver Center Pilot. Grant Number: P30-DK034987
- National Heart, Lung, and Blood Institute. Grant Numbers: R01 HL64793, R01 HL61371, R01 HL081190, RO1 HL096670
Additional Supporting Information may be found in the online version of this article.
|HEP_24200_sm_suppinfofig1.tif||4711K||Supplemental Figure 1 Nogo-B gene deletion significantly decreases cholangiocyte in cholestatic livers. Livers were isolated from wildtype (WT) and Nogo-B KO (NGB KO) mice 4 weeks after sham or bile duct ligation (BDL) surgery. N-5-6 per group. The CK19 positive area was quantified using ImageJ. Representative images are shown.|
|HEP_24200_sm_suppinfofig2.tif||7790K||Supplemental Figure 2 Nogo-B gene deletion does not affect Kupffer cell infiltration in the liver after bile duct ligation (BDL). No differences were seen in F4/80 immunostaining, a Kupffer cell marker, four weeks after BDL. Representative images of F4/80 staining are shown. Arrows; F4/80 positive Kupffer cells. Scale bar; 200 μm.|
|HEP_24200_sm_suppinfofig3.tif||6366K||Supplemental Figure 3 Nogo-B is localized to non-parenchymal cells in regions of fibrotic areas of cholestatic liver. Nogo-B in red and β-smooth muscle actin (?-SMA) in green. Nogo-B staining is prominent in fibrotic areas (arrow), endothelial cells (asterisks; vessel lumen) and bile ducts (arrow head). Corresponding magnified images of the upper panel are shown below. Scale bar; 200 μm.|
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