SEARCH

SEARCH BY CITATION

Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_24217_sm_suppinfofig1-1.tif1519KSupporting Fig. 1. (A-F). Representative forward and reverse sequencing chromatograms from the indicated gene regions. The respective amino acid substitutions are indicated in the lines above the chromatograms: (A) wild-type TERT exon 1 (left side) and a patient with a heterozygous c.37C>A and c.40C>A variant (right side); (B) wild-type TERT exon 1 (left side) and an individual with a heterozygous c.193C>G variant (right side); (C) wild-type TERT exon 2 (left side) and a patient with a heterozygous c.1138C>T variant (right side); (D) wild-type TERT exon 2 (left side) and an individual with a heterozygous c.1336C>A variant (right side); (E) wild-type TERT exon 10 (left side) and a patient with a heterozygous c.2638G>T and c.2345 C>T variant (right side); (F) wild-type TERT exon 16 (left side) and an individual with a heterozygous c.3346G>C variant (right side); (G) wild-type TERT exon 16 (left side), a patient with a heterozygous c.3325G>A variant (middle), and a patient with a homozygous c.3325G>A variant (right side). The homozygous nature of the mutation is evident by the presence of a mutant allele sequence only while the heterozygous form shows both wild-type and mutant allele sequences.
HEP_24217_sm_suppinfofig1-2.tif2237KSupporting Information Figure 1-2
HEP_24217_sm_suppinfofig2.tif1496KSupporting Fig. 2. The pie charts show the overall allele frequency (left sides) and the distribution (right side) of telomerase gene mutation in (A) cirrhosis patients and (B) non-cirrhotic controls.
HEP_24217_sm_suppinfofig3.tif1093KSupporting Fig. 3. The pie charts show the distribution of ethnicities of the complete study cohort (A) and mutation carriers (B).
HEP_24217_sm_suppinfotab1.doc59KSupporting Table 1. Primers used for sequencing of indicated exons of TERT and of the TERC gene
HEP_24217_sm_suppinfotab2.doc34KSupporting Table 2. Primers used to generate expression constructs for cirrhosis-associated TERT-mutations using site-directed mutagenesis
HEP_24217_sm_suppinfotab3.doc139KSupporting Table 3. Distribution of hypomorphic telomerase reverse transcriptase variants in the study and control groups

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.