We appreciate Yu's interest and comments regarding the definition of early virological response (EVR) in our recent article on hepatitis C virus (HCV) genotype 6 therapy.1 We defined EVR as an undetectable HCV RNA level at week 12. In the study, all patients who achieved partial EVR (defined as a 2-log10 decline in the baseline HCV RNA level) also achieved complete EVR, and a separate analysis of these two treatment endpoints would not have yielded additional information. We appreciate the opportunity to make this clarification.
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Mindie Nguyen M.D.*, Khoa Lam M.D. , * Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, Pacific Health Foundation, San Jose, CA, Department of Medicine, University of California San Francisco, San Francisco, CA.