• Potential conflict of interest: Nothing to report.


We appreciate Yu's interest and comments regarding the definition of early virological response (EVR) in our recent article on hepatitis C virus (HCV) genotype 6 therapy.1 We defined EVR as an undetectable HCV RNA level at week 12. In the study, all patients who achieved partial EVR (defined as a 2-log10 decline in the baseline HCV RNA level) also achieved complete EVR, and a separate analysis of these two treatment endpoints would not have yielded additional information. We appreciate the opportunity to make this clarification.

Mindie Nguyen M.D.*, Khoa Lam M.D.† ‡, * Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, † Pacific Health Foundation, San Jose, CA, ‡ Department of Medicine, University of California San Francisco, San Francisco, CA.