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Steatohepatitis/Metabolic Liver Disease

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Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects†‡

  1. Sven Haufe1,2,
  2. Stefan Engeli2,
  3. Petra Kast1,
  4. Jana Böhnke1,
  5. Wolfgang Utz3,
  6. Verena Haas1,
  7. Mario Hermsdorf1,
  8. Anja Mähler1,
  9. Susanne Wiesner1,
  10. Andreas L. Birkenfeld4,
  11. Henrike Sell5,
  12. Christoph Otto1,
  13. Heidrun Mehling1,
  14. Friedrich C. Luft1,
  15. Juergen Eckel5,
  16. Jeanette Schulz-Menger3,
  17. Michael Boschmann1,
  18. Jens Jordan2,§,*

Article first published online: 11 MAR 2011

DOI: 10.1002/hep.24242

Issue

Hepatology

Hepatology

Volume 53, Issue 5, pages 1504–1514, May 2011

Additional Information

How to Cite

Haufe, S., Engeli, S., Kast, P., Böhnke, J., Utz, W., Haas, V., Hermsdorf, M., Mähler, A., Wiesner, S., Birkenfeld, A. L., Sell, H., Otto, C., Mehling, H., Luft, F. C., Eckel, J., Schulz-Menger, J., Boschmann, M. and Jordan, J. (2011), Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology, 53: 1504–1514. doi: 10.1002/hep.24242

Author Information

  1. 1

    Franz Volhard Clinical Research Center at the Experimental and Clinical Research Center, Charité University Medical School and Max Delbrück Center for Molecular Medicine, Berlin, Germany

  2. 2

    Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany

  3. 3

    Franz Volhard Clinic, Charité University Medical School and Helios Klinikum, Berlin, Germany

  4. 4

    Department of Endocrinology, Diabetes and Nutrition, Charité University Medical School, Berlin, Germany, and German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany

  5. 5

    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Düsseldorf, Germany

  1. §

    fax: +49-511-532 2750.

*Institute for Clinical Pharmacology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    This study was part of a joint project between metanomics GmbH (Berlin, Germany) and Charité - University Medical School which was supported by the Federal Ministry of Education and Research (BMBF-0313868) and in part by the Commission of the European Communities (Collaborative Project ADAPT, Contract No. HEALTH-F2-2008-201100) and the German Obesity Network of Competence (Collaborative Project ADIPOSETARGET, 01 Gl0830) (to S.E. and J.J). Clinical trial number: ClinicalTrials.gov NCT00956566

  3. §

    fax: +49-511-532 2750.

Publication History

  1. Issue published online: 22 APR 2011
  2. Article first published online: 11 MAR 2011
  3. Accepted manuscript online: 15 FEB 2011 12:16PM EST
  4. Manuscript Accepted: 2 FEB 2011
  5. Manuscript Received: 26 OCT 2010

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Abstract

Obesity-related hepatic steatosis is a major risk factor for metabolic and cardiovascular disease. Fat reduced hypocaloric diets are able to relieve the liver from ectopically stored lipids. We hypothesized that the widely used low carbohydrate hypocaloric diets are similarly effective in this regard. A total of 170 overweight and obese, otherwise healthy subjects were randomized to either reduced carbohydrate (n = 84) or reduced fat (n = 86), total energy restricted diet (−30% of energy intake before diet) for 6 months. Body composition was estimated by bioimpedance analyses and abdominal fat distribution by magnetic resonance tomography. Subjects were also submitted to fat spectroscopy of liver and oral glucose tolerance testing. In all, 102 subjects completed the diet intervention with measurements of intrahepatic lipid content. Both hypocaloric diets decreased body weight, total body fat, visceral fat, and intrahepatic lipid content. Subjects with high baseline intrahepatic lipids (>5.56%) lost ≈7-fold more intrahepatic lipids compared with those with low baseline values (<5.56%) irrespective of diet composition. In contrast, changes in visceral fat mass and insulin sensitivity were similar between subgroups, with low and high baseline intrahepatic lipids. Conclusion: A prolonged hypocaloric diet low in carbohydrates and high in fat has the same beneficial effects on intrahepatic lipid accumulation as the traditional low-fat hypocaloric diet. The decrease in intrahepatic lipids appears to be independent of visceral fat loss and is not tightly coupled with changes in whole body insulin sensitivity during 6 months of an energy restricted diet. (HEPATOLOGY 2011)

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