These authors contributed equally to this work.
Article first published online: 22 APR 2011
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 53, Issue 5, pages 1494–1503, May 2011
How to Cite
Schurich, A., Khanna, P., Lopes, A. R., Han, K. J., Peppa, D., Micco, L., Nebbia, G., Kennedy, P. T.F., Geretti, A.-M., Dusheiko, G. and Maini, M. K. (2011), Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection. Hepatology, 53: 1494–1503. doi: 10.1002/hep.24249
Potential conflict of interest: Dr. Dusheiko consults for, serves on the speaker's bureau of, and received grants from Bristol-Myers Squibb, Gilead, and Roche.
Funded by Medical Research Council Awards G108515 and G0801213 (to M.K.M.) and by an unrestricted infrastructure grant from Roche and Schering Plough (to G.D.).
- Issue published online: 22 APR 2011
- Article first published online: 22 APR 2011
- Accepted manuscript online: 25 FEB 2011 08:59AM EST
- Manuscript Accepted: 3 FEB 2011
- Manuscript Received: 28 OCT 2010
Additional Supporting Information may be found in the online version of this article.
|HEP_24249_sm_suppinfofig1.tif||148K||Supporting Figure 1. Upregulation of CTLA-4 in responses to CMV and EBV in patients with CHB compared to healthy controls. Cumulative data of CTLA-4 expression in virus-specific CD8 T cells in CHB and healthy controls after 10 days culture and restimulation with HLA-A2 restricted immunodominant peptides derived from CMV or EBV, or OLP spanning the CMV pp65 protein.|
|HEP_24249_sm_suppinfofig2.tif||133K||Supporting Figure 2. CD4 T cells in CHB have an increased propensity to upregulate CTLA-4 compared to those from healthy controls. Cumulative data showing intracellular CTLA-4 after mitogenic stimulation in CD4 T cells from healthy controls and HBV infected individuals with low and high viral load (VL).|
|HEP_24249_sm_suppinfofig3.tif||111K||Supporting Figure 3. The propensity to upregulate CTLA-4 correlates with sAg levels in CHB patients. HBV multimer+ cells are stimulated with cognate peptide stained for intracellular CTLA-4.|
|HEP_24249_sm_suppinfofig4.tif||293K||Supporting Figure 4. No reduction of CTLA-4 and Bim in HBV-specific CD8 T cells upon viral load reduction with potent antivirals. Individual data for patients followed pre and 13-18 months after starting antivirals, showing no significant sustained changes in HBV-specific CD8 frequency or levels of Bim and CTLA-4 in these cells.|
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