Potential conflict of interest: Nothing to report.
1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
Hepatology Elsewhere
You have full text access to this OnlineOpen article
The hepcidin circuits act: Balancing iron and inflammation†
Article first published online: 22 APR 2011
DOI: 10.1002/hep.24267
Copyright © 2011 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Maliken, B. D., Nelson, J. E., Kowdley, K. V. (2011), The hepcidin circuits act: Balancing iron and inflammation. Hepatology, 53: 1764–1766. doi: 10.1002/hep.24267
- †
Publication History
- Issue published online: 22 APR 2011
- Article first published online: 22 APR 2011
- Manuscript Accepted: 16 FEB 2011
References
- 1, , , , , , et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306: 2090-2093.
- 2, , , . Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810.
- 3, . Hepcidin, the iron watcher. Biochimie 2009; 91: 1223-1228.
- 4, , , . Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr 2007; 137: 2366-2370.
- 5, , , , , , et al. Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53. Br J Haematol 2007; 138: 253-262.
- 6, . Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism. Haematologica 2009; 94: 1185-1188.
- 7, , , , , , et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 2006; 38: 531-539.
- 8, , , , , , et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2005; 2: 399-409.
- 9, , , , , , et al. SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 2010; 115: 2657-2665.
- 10, , , , , . The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab 2008; 8: 502-511.
- 11, , , , , , et al. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 2008; 40: 569-571.
- 12, . Interleukin-6 induces hepcidin expression through STAT3. Blood 2006; 108: 3204-3209.
- 13, , , , , . STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 2007; 109: 353-358.
- 14, , , , , , et al. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell 2007; 18: 2569-2578.
- 15, , , , , , et al. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest 2010; 120: 2395-2405.
- 16, , , , , . A role for tumour necrosis factor alpha in human small bowel iron transport. Biochem J 2005; 390( pt 2): 437-446.
- 17, , , , , , et al. Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells. J Leukoc Biol 2003; 74: 287-294.
- 18, , , , , , et al. Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2. Blood 2009; 114: 3642-3651.