Article first published online: 25 MAY 2011
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 53, Issue 6, pages 2112–2121, June 2011
How to Cite
Breuhahn, K., Gores, G. and Schirmacher, P. (2011), Strategies for hepatocellular carcinoma therapy and diagnostics: Lessons learned from high throughput and profiling approaches. Hepatology, 53: 2112–2121. doi: 10.1002/hep.24313
Potential conflict of interest: Nothing to report.
Supported by the German Research Foundation (SFB/TRR77), the Helmholtz Alliance on Immunotherapy of Cancer, and the German Federal Ministry for Education and Research (Virtual Liver Network).
- Issue published online: 25 MAY 2011
- Article first published online: 25 MAY 2011
- Accepted manuscript online: 23 MAR 2011 09:54AM EST
- Manuscript Accepted: 6 MAR 2011
- Manuscript Received: 14 DEC 2010
Over the last decade, numerous small and high-dimensional profiling analyses have been performed in human hepatocellular carcinoma (HCC), which address different levels of regulation and modulation. Because comprehensive analyses are lacking, the following review summarizes some of the general results and compares them with insights from other tumor entities. Particular attention is given to the impact of these results on future diagnostic and therapeutic approaches. (HEPATOLOGY 2011;)