These authors contributed equally to this study.
Version of Record online: 25 MAY 2011
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 53, Issue 6, pages 2016–2026, June 2011
How to Cite
Kuramitsu, K., Gallo, D., Yoon, M., Chin, B. Y., Csizmadia, E., Hanto, D. W. and Otterbein, L. E. (2011), Carbon monoxide enhances early liver regeneration in mice after hepatectomy. Hepatology, 53: 2016–2026. doi: 10.1002/hep.24317
Potential conflict of interest: Nothing to report.
Supported in part by NIH R01GM088666-01 to L.E.O. and the Julie Henry Fund at the Transplant Institute of the BIDMC.
- Issue online: 25 MAY 2011
- Version of Record online: 25 MAY 2011
- Accepted manuscript online: 23 MAR 2011 09:54AM EST
- Manuscript Accepted: 12 MAR 2011
- Manuscript Received: 20 MAY 2010
Additional Supporting Information may be found in the online version of this article.
|HEP_24317_sm_suppinfoFig1.tif||812K||Liver sections stained for Prohibitin as a marker of mitochondrial stability and function and are localized in the mitochondrial and associated with cell proliferation. Sections were processed as described in Methods and stained using an anti-prohibitin antibody (R&D). Briefly, tissues were harvested 24 hr after 70% partial hepatectomy. Animals (n=4/group) were treated with CO (1 hr pretreatment at 250 ppm) or Air as control. Note little to no positive staining in livers from Naïve or Air-treated, hepatectomized mice compared to the greater amount of prohibitin-positive cells in the livers from CO treated, hepatectomized mice. Arrows indicate positively-stained cells. Naïve is 20× and Air and CO are 40× magnification. Images are representative of 10 fields of view from 4 mice/group. Bar = 20μm.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.