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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_24517_sm_SuppInfoFig1.tif649KFig. SI. Body weight. Various strains of mice were fed a HFD and a control diet for 12 weeks. Body weight measured and recorded weekly.
HEP_24517_sm_SuppInfoFig2.tif645KFig. S2. Body weight. Various strains of mice were fed an ETCH diet and pair fed diet for 4 weeks . Body weight was measured before and after feeding.
HEP_24517_sm_SuppInfoFig3.tif633KFig. S3. Blood ethanol concentrations after gavage of ethanol. Various strains of mice were gavaged with ethanol (59/kg body weight). Blood ethanol concentrations were measured 2 hours later.
HEP_24517_sm_SuppInfoFig4.tif3599KSupplemental Fig. S4. An additional deletion of IL-6 restores ETOH-induced steatosis and elevation of serum ALT in IL-104 mice. Male C57BL/6J (WT), IL-lO-′-, IL-6 ′-, IL-10′1L-6′ mice were fed ETCH diet or pair-fed for 4 weeks. (A) H&E staining of liver sections from ETCH- and pair-fed mice. (B) Liver triglyceride levels (upper panel) and serum ALT levels (lower panel). (C) Real-time PCR analyses of hepatic inflammatory markers CCR2 and F480. (D) Real-time PCR analyses of hepatic cytokines. (E) Serum levels of proinflammatory cytokines. *p<005 **D<QQ in comparison with corresponding WT group; # P<0.05, ## P<0.05 in comparison with corresponding IL-i 0′ group.
HEP_24517_sm_SuppInfoFig5.tif3031KSupplemental Fig. S5. An additional deletion of hepatocyte STAT3 restores ETOHinduced steatosis and elevation of serum ALT in IL-104 mice. WT, IL-10′, IL-10′ STAT3HeP-/- mice were fed ETCH diet or pair-fed for 4 weeks. (A) H&E staining of liver sections from ETCH and control fed mice. (B) Liver triglyceride levels (upper panel) and serum ALT levels (lower panel). (C) Real-time PCR analyses of hepatic inflammatory markers CCR2 and F4180. (D) Real-time PCR analyses of hepatic cytokines. (E) Serum levels of proinflammatory cytokines. # P<0.05, P<0.05. Statistical analyses were only performed between IL-i OSTAT3HeP′ dKC and IL-i 0′ mice. # P<0.05, ## P<0.01.
HEP_24517_sm_SuppInfo.doc50KSupporting Informaion

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