These authors contributed equally to the study.
Article first published online: 30 NOV 2011
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 54, Issue 6, pages 2159–2172, December 2011
How to Cite
Cardinale, V., Wang, Y., Carpino, G., Cui, C.-B., Gatto, M., Rossi, M., Bartolomeo Berloco, P., Cantafora, A., Wauthier, E., Furth, M. E., Inverardi, L., Dominguez-Bendala, J., Ricordi, C., Gerber, D., Gaudio, E., Alvaro, D. and Reid, L. (2011), Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets. Hepatology, 54: 2159–2172. doi: 10.1002/hep.24590
Potential conflict of interest: Dr. Reid consults, received grants from, and holds intellectuals property rights for Vesta and GigaCyte. She also received grants from and holds intellectual property rights for Vertex.
Support: (UNC) Funding derived from a grant from the North Carolina Biotechnology Center (NCBC), GigaCyte Biotech (Branford, CT), Vesta Therapeutics (Bethesda, MD), and from NIH grants (AA014243, IP30-DK065933), NIDDK Grant (DK34987), and an NCI grant (CA016086); (Sapienza University) Dr. Cardinale received salary support from a scholarship from Sapienza University of Rome for the studies that he did at UNC. D. Alvaro and V. Cardinale were supported by FIRB grant no. RBAP10Z7FS_004; D. Alvaro, V. Cardinale, E. Gaudio, and G. Carpino were supported by a grant from Agenzia Regionale Del Lazio Per I Trapianti E Le Patologie Connesse; E. Gaudio was supported by MIUR grants: PRIN#2007, prot. 2007HPT7BA_001 and Federate Athenaeum funds from the University Sapienza of Rome; (Diabetes Research Institute) The studies were funded by grants from NIH, the Juvenile Diabetes Research Foundation, ADA, and the Diabetes Research Institute Foundation.
Patent: A patent on the biliary tree stem cells was filed in November, 2009 and is jointly owned by UNC in Chapel Hill, NC, and Sapienza University in Rome, Italy.
- Issue published online: 30 NOV 2011
- Article first published online: 30 NOV 2011
- Accepted manuscript online: 1 AUG 2011 08:19AM EST
- Manuscript Accepted: 20 JUL 2011
- Manuscript Revised: 14 JUL 2011
- Manuscript Received: 14 MAY 2011
- 5http://www.ncbi.nlm.nih.gov/pubmed?term=%22Moss%20N%22%5BAuthor%5D et al. Human hepatic stem cells from fetal and postnatal donors. J Exp Med 2007; 204: 1973-1987., , , , , ,
- 14http://www.ncbi.nlm.nih.gov/pubmed?term=%22Slack% 20JM%22%5BAuthor%5D et al. Beta cells occur naturally in extrahepatic bile ducts of mice. J Cell Sci 2007; 120: 239-245., , , , , ,
- 15http://www.ncbi.nlm.nih.gov/pubmed?term=%22Whitsett%20JA%22% 5BAuthor%5D et al. SOX 17 regulates lineage segregation of ventral foregut progenitor cells. Dev Cell 2009; 17: 62-74., , , , , ,
- 16http://www.ncbi.nlm.nih.gov/pubmed?term=%22Hosokawa%20S% 22%5BAuthor%5D et al. Continuous cell supply from a Sox 9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 2011; 43: 34-41., , , , , ,
- 31http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gentile%20R% 22%5BAuthor%5D et al. Intra-hepatic and extra-hepatic cholangiocarcinoma: new insight into epidemiology and risk factors (review). World J Gastrointest Oncol 2010; 2: 407-416., , , , , ,