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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_24606_sm_SuppFig1.tif846KSupporting Fig. 1. CpG islands of miR-200a locus in HCC and matched controls are both hypermethylated. Methylation pattern of miR-200a locus was analyzed by bisulfite sequencing. Shown is an example of the five HCC samples undergone epigenetic research (p = 0.28, Wilcoxon rank-sum test). The other samples showed a similar manner.
HEP_24606_sm_SuppFig2.tif4635KSupporting Fig. 2. Effects of HDAC4 on the expression of the miR-200 family. (A) The expression of the miR-200 family in SMMC-7721 and HepG2 cells. (B) Expression level of the miR-200 family after the transfection of pcDNA3.1-HDAC4 or pcDNA3.1 into SMMC-7721 and HepG2 cells. (C) Expression level of the miR-200 family after the transfection of HDAC4 siRNA or the control siRNA into SMMC-7721 and HepG2 cells. Data are presented as the mean ± standard error, based on at least three independent experiments. *P < 0.05.
HEP_24606_sm_SuppFig3.tif1205KSupporting Fig. 3. Effects of the miR-200 family on the expression of HDAC4. The amounts of protein were quantified and indicated relative to the signals from miRNAs negative control-transfected cells (set to 1). Data are presented as the mean of three independent experiments.
HEP_24606_sm_SuppTable1.doc83KSupporting Table 1. Oligonucleotide Sequences used in this study
HEP_24606_sm_SuppInfo.doc73KSupporting Information

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