Article first published online: 30 NOV 2011
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 54, Issue 6, pages 2198–2207, December 2011
How to Cite
Paris, A. J., Snapir, Z., Christopherson, C. D., Kwok, S. Y., Lee, U. E., Ghiassi-Nejad, Z., Kocabayoglu, P., Sninsky, J. J., Llovet, J. M., Kahana, C. and Friedman, S. L. (2011), A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis. Hepatology, 54: 2198–2207. doi: 10.1002/hep.24608
Potential conflict of interest: Dr. Friedman received grants from Celera. Drs. Kwok, Sninsky, and Christopherson own stocks in Celera.
The work was supported by Celera (to S.L.F.) and National Institutes of Health grant RO1 DK56621 (to S.L.F.), the Israel Science Foundation (to C.K.), and by a grant from the Deutsche Forschungsgemeinschaft (to P.K.). A.J.P. was supported by a Doris Duke Clinical Research Fellowship and an Alpha Omega Alpha Student Research Fellowship.
- Issue published online: 30 NOV 2011
- Article first published online: 30 NOV 2011
- Accepted manuscript online: 11 AUG 2011 09:27AM EST
- Manuscript Accepted: 29 JUL 2011
- Manuscript Received: 7 SEP 2010
Additional Supporting Information may be found in the online version of this article.
|HEP_24608_sm_SuppFig1.tif||2314K||Supporting Figure 1. LX2 cells expressing the AzI SNP minigene displayed a 1.37-fold increase (P = 0.05) in AzI splice variant 8 (AzI SV8) mRNA relative to cells expressing the WT minigene.|
|HEP_24608_sm_SuppTable1.doc||28K||Supporting Table 1. Only AZIN1 SV1, SV2 & SV7 were reliably detectible in PBMC mRNA. When expression was normalized to total AZIN1 expression, there was only a significant difference in AZIN1 SV2 expression in the presence of the fibrosis-protective polymorphism.|
|HEP_24608_sm_SuppTable2.doc||29K||Supporting Table 2. To evaluate a possible confounding gender bias in our analysis of AZIN1 SV2 expression in PBMCs from healthy donors, we sought a statistical difference in expression of SV2 between males and females. However, there was no statistical evidence to suggest that SV2 expression is influenced by gender.|
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