fax: 301-402-0491
AASLD Practice Guideline
An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases†‡§
Article first published online: 26 SEP 2011
DOI: 10.1002/hep.24641
Copyright © 2011 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Ghany, M. G., Nelson, D. R., Strader, D. B., Thomas, D. L. and Seeff, L. B. (2011), An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology, 54: 1433–1444. doi: 10.1002/hep.24641
- †
Potential conflict of interest: Dr. Nelson receives research support from Vertex, Merck, Phamassett, Genentech/Roche, Gilead, Bristol-Myers Squibb, Tibotec, Bayer/Onyx and serves on advisory boards of Merck, Pharmassett, Genentech/Roche, Gilead, Tibotec, and Bayer/Onyx, and is a consultant for Vertex.Dr. Thomas receives research support from Merck, Gilead and serves on a Merck advisory board.Dr. Ghany, Dr. Seeff, and Dr. Strader have nothing to report.
- ‡
Consultant in Hepatology for the U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20943. The views expressed in the document are those of the authos and not of the Food and Drug Administration.
- §
All AASLD Practice Guidelines are updated annually. If you are viewing a Practice Guideline that is more than 12 months old, please visit www.aasld.org for an update in the material.
- ¶
fax: 301-402-0491
Publication History
- Issue published online: 27 SEP 2011
- Article first published online: 26 SEP 2011
- Accepted manuscript online: 2 SEP 2011 09:28AM EST
- Manuscript Received: 29 AUG 2011
- Manuscript Accepted: 29 AUG 2011
- Abstract
- Article
- References
- Cited By
Cited in:
- CrossRef
This article has been cited by:
- 1[Draft] Guidance for Industry: Enrichment Strategies for Clinical Trials to Support Approval of Human Drug and Biological Products, Biotechnology Law Report, 2013, 32, 1-2, 58
- 2, , , , , , , , A 24-week dietary and physical activity lifestyle intervention reduces hepatic insulin resistance in the obese with chronic hepatitis C, Liver International, 2013, 33, 3Direct Link:
- 3, , , , , , , , , , , , , A model to predict the response to therapy against hepatitis C virus (HCV) including low-density lipoprotein receptor genotype in HIV/HCV-coinfected patients, Journal of Antimicrobial Chemotherapy, 2013, 68, 4, 915
- 4, , , , , , , , , , , , A phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1, Journal of Hepatology, 2013,
- You have free access to this content5, , , , , , , , Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV-infected, evaluated patients, Alimentary Pharmacology & Therapeutics, 2013, 37, 4Direct Link:
- 6, , , , , , , Anti-viral triple therapy with telaprevir in haemodialysed HCV patients: Is it feasible?, Journal of Clinical Virology, 2013, 56, 2, 146
- 7, , , Antiviral therapy of symptomatic HCV-associated mixed cryoglobulinemia: Meta-analysis of clinical studies, Journal of Medical Virology, 2013, 85, 6Direct Link:
- 8
- 9, , , , , , , Boceprevir for previously untreated patients with chronic hepatitis C Genotype 1 infection: a US-based cost-effectiveness modeling study, BMC Infectious Diseases, 2013, 13, 1, 190
- 10, , , , , , , , , , , , Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir, Journal of Hepatology, 2013, 58, 4, 646
- 11, , , , Closing in on the Target: Sustained Virologic Response in Hepatitis C Virus Genotype 1 Infection Response-Guided Therapy, Clinical Infectious Diseases, 2013, 56, 10, 1466
- 12, , , , , Cost-effectiveness of Screening for Chronic Hepatitis C Infection in the United States, Clinical Infectious Diseases, 2013, 56, 10, 1382
- 13, , Current and Future Therapies for Hepatitis C Virus Infection, New England Journal of Medicine, 2013, 368, 20, 1907
- 14, Current Management of Hepatitis C Virus Infection in Patients With HIV Co-infection, Journal of Infectious Diseases, 2013, 207, suppl 1, S26
- 15, , , , , , , , , , , , , , , , Cutaneous sarcoidosis in a chronic hepatitis C patient receiving pegylated interferon and ribavirin therapy, Hepatology Research, 2013, 43, 5Direct Link:
- 16, , , Cyclophilin Inhibitors for Hepatitis C Therapy, Clinics in Liver Disease, 2013, 17, 1, 129
- 17, , , , , , , , , , , , , , , , , , , , , Delayed versus immediate treatment for patients with acute hepatitis C: a randomised controlled non-inferiority trial, The Lancet Infectious Diseases, 2013,
- 18, , , , , , , , Development of a multiplex phenotypic cell-based high throughput screening assay to identify novel hepatitis C virus antivirals, Antiviral Research, 2013, 99, 1, 6
- 19, , Direct-Acting Antiviral Agents for Hepatitis C Virus Infection, Annual Review of Pharmacology and Toxicology, 2013, 53, 1, 427
- 20, , , Directly acting antivirals for the treatment of chronic hepatitis C: Unresolved topics from registration trials, Digestive and Liver Disease, 2013, 45, 1, 1
- 21, , , , , Effect of Ritonavir-Boosted Danoprevir, a Potent Hepatitis C Virus Protease Inhibitor, on QTc Interval in Healthy Subjects: Results from a Thorough QT Study, Drug Development Research, 2013, 74, 3Direct Link:
- 22, , , , Effect of telaprevir on the pharmacokinetics of sirolimus in liver transplant recipients, Liver Transplantation, 2013, 19, 4Direct Link:
- 23, , , , , Elimination Half-Life May Explain the Relative Efficacy of Boceprevir and Telaprevir in the Treatment of Hepatitis C Virus Genotype 1, Clinical Infectious Diseases, 2013, 56, 11, 1677
- 24, , , , , , , , , , , Evaluating the Role of Macrocycles in the Susceptibility of Hepatitis C Virus NS3/4A Protease Inhibitors to Drug Resistance, ACS Chemical Biology, 2013, 130501131703009
- 25, , , , Evaluation of the Significance of Pretreatment Liver Biopsy and Baseline Mental Health Disorder Diagnosis on Hepatitis C Treatment Completion Rates at a Veterans Affairs Medical Center, Hepatitis Research and Treatment, 2013, 2013, 1
- 26, , , , , , Evolutionary dynamics of the E1–E2 viral populations during combination therapy in non-responder patients chronically infected with hepatitis C virus subtype 1b, Infection, Genetics and Evolution, 2013, 13, 1
- 27, , , , , , , , Frequency and predictors of no treatment in anti-hepatitis C virus-positive patients at tertiary liver centers in Greece, European Journal of Gastroenterology & Hepatology, 2013, 25, 5, 587
- 28, , Futility of antiviral treatments for hepatitis C: An evolving concept entering the direct antiviral agents era, Digestive and Liver Disease, 2013, 45, 5, 356
- 29, , , , , , , , , , , , , , , , , , , , , , , HCV NS5A Replication Complex Inhibitors. Part 4.(1) Optimization for Genotype 1a Replicon Inhibitory Activity, Journal of Medicinal Chemistry, 2013, 130410085046001
- 30, , , , HCV RNA Viral Load Assessments in the Era of Direct-Acting Antivirals, The American Journal of Gastroenterology, 2013, 108, 4, 471
- 31, , , , , , Hepatitis C Virus Infection, Mixed Cryoglobulinemia, and Kidney Disease, American Journal of Kidney Diseases, 2013, 61, 4, 623
- 32
- You have free access to this content33, , How to optimize HCV therapy in genotype 1 patients: predictors of response, Liver International, 2013, 33,Direct Link:
- You have free access to this content34, , How to optimize HCV therapy in genotype 2 patients, Liver International, 2013, 33,Direct Link:
- 35, , IL-28B polymorphisms and the response to antiviral therapy in HCV genotype 2 and 3 varies by ethnicity: a meta-analysis, Journal of Viral Hepatitis, 2013, 20, 6Direct Link:
- 36, IL28B in the Era of Direct-acting Antivirals for Hepatitis C, Journal of Clinical Gastroenterology, 2013, 47, 3, 222
- 37, , , , Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: A review and analysis of 36 cases, Journal of the European Academy of Dermatology and Venereology, 2013, 27, 6Direct Link:
- 38, , , , Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: Exploring a potential strategy for mechanism-based HCV drug design, Antiviral Research, 2013, 98, 2, 144
- 39, , , , , , , , , , , , , Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection, Gastroenterology, 2013, 144, 2, 402
- 40
- 41, , , , , , , , , , , , , Intensified Peginterferon α-2a Dosing Increases Sustained Virologic Response Rates in Heavy, High Viral Load Hepatitis C Genotype 1 Patients With High Low-density Lipoprotein, Journal of Clinical Gastroenterology, 2013, 47, 3, 271
- 42, Interferon-Free Regimens for Chronic Hepatitis C—A Step Forward, Journal of Clinical and Experimental Hepatology, 2013, 3, 1, 76
- 43, , , , , , , , , , , , Intrahepatic mRNA levels of SOCS1 and SOCS3 are associated with cirrhosis but do not predict virological response to therapy in chronic hepatitis C, Liver International, 2013, 33, 1Direct Link:
- 44, , , , Is the HCV Pipeline Heading in the Right Direction?, Gastroenterology, 2013, 144, 3, 482
- 45, , , Magnetic resonance elastography of liver: Technique, analysis, and clinical applications, Journal of Magnetic Resonance Imaging, 2013, 37, 3Direct Link:
- 46, , Management of the Transplant Recipient with Chronic Hepatitis C, Clinics in Liver Disease, 2013, 17, 1, 73
- You have free access to this content47, , , , , , , , , Meta-analysis: pegylated interferon α-2a achieves higher early virological responses than α-2b in chronic hepatitis C, Alimentary Pharmacology & Therapeutics, 2013, 37, 11Direct Link:
- 48, , , , , , , Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient, Clinical Journal of Gastroenterology, 2013, 6, 2, 160
- 49, , , , , Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors, Journal of Clinical Virology, 2013, 57, 1, 13
- 50, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Noninvasive Serum Fibrosis Markers for Screening and Staging Chronic Hepatitis C Virus Patients in a Large US Cohort, Clinical Infectious Diseases, 2013,
- 51, , , Omics and Drug Response, Annual Review of Pharmacology and Toxicology, 2013, 53, 1, 475
- You have free access to this content52, , Optimal treatment with boceprevir for chronic HCV infection, Liver International, 2013, 33,Direct Link:
- You have free access to this content53, , Patients with HCV and F1 and F2 fibrosis stage: treat now or wait?, Liver International, 2013, 33,Direct Link:
- 54, , , , , , , , , , Pegylated interferon plus ribavirin is suboptimal in IL28B CC carriers without rapid response, Journal of Infection, 2013,
- 55, , , , , PNAS Plus: NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase, Proceedings of the National Academy of Sciences, 2013, 110, 5, E348
- 56, , , , , , , , , , , , , , Prediction of a favorable clinical course in hepatitis C virus carriers with persistently normal serum alanine aminotransferase levels: A long-term follow-up study, Hepatology Research, 2013, 43, 5Direct Link:
- 57, , , , , , , , , , , , , Profound week 4 interferon responsiveness is mandatory for hepatitis C genotype 1 patients with unfavorable IL-28B genotype, Journal of Clinical Virology, 2013, 56, 4, 293
- You have free access to this content58, , Reactivation of hepatitis viruses following immunomodulating systemic chemotherapy, Hepatology Research, 2013, 43, 2Direct Link:
- 59, , , , , , , , , , , , , Response-guided telaprevir therapy in prior relapsers? The role of bridging data from treatment-naïve and experienced subjects, Hepatology, 2013, 57, 3Direct Link:
- You have free access to this content60, , Review article: prescribing medications in patients with cirrhosis – a practical guide, Alimentary Pharmacology & Therapeutics, 2013, 37, 12Direct Link:
- You have free access to this content61, , , Review article: the treatment of genotype 1 chronic hepatitis C virus infection in liver transplant candidates and recipients, Alimentary Pharmacology & Therapeutics, 2013, 37, 7Direct Link:
- 62, , , , , , , , , , , , Role of hepatitis C virus substitutions and interleukin-28B polymorphism on response to peginterferon plus ribavirin in a prospective study of response-guided therapy, Journal of Viral Hepatitis, 2013, 20, 6Direct Link:
- 63, , , Role of Liver Biopsy in the Era of Direct-Acting Antivirals, Current Gastroenterology Reports, 2013, 15, 2
- 64, , , Safety aspects of protease inhibitors for chronic hepatitis C: adverse events and drug-to-drug interactions, The Brazilian Journal of Infectious Diseases, 2013, 17, 2, 194
- 65, , , , , , Sequential induction of type I and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist, Journal of Hepatology, 2013, 58, 4, 743
- 66, , , , , , , , , , , , , , , , , , , , , , , , Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection, New England Journal of Medicine, 2013, 368, 20, 1878
- 67, , , , , , , , , , , , , , , , , , , , , , , , , , , , , Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial, The Lancet Infectious Diseases, 2013, 13, 5, 401
- 68, , , , , , , , , , , , , , , , , , , , Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial, The Lancet, 2013,
- 69, , , , , , , , , , Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis, Antiviral Research, 2013, 98, 3, 373
- You have free access to this content70, , , , , , , , Sustained virologic response after therapy with the HCV protease inhibitor narlaprevir in combination with peginterferon and ribavirin is durable through long-term follow-up, Journal of Viral Hepatitis, 2013, 20, 4Direct Link:
- 71, , Systematic review: Asian patients with chronic hepatitis C infection, Alimentary Pharmacology & Therapeutics, 2013, 37, 10Direct Link:
- 72, , , Telaprevir to Boceprevir Switch Highlights Lack of Cross-Reactivity, Clinical Infectious Diseases, 2013, 56, 4, 552
- 73, , , , , , , , , The changing face of hepatitis C in the new era of direct-acting antivirals, Antiviral Research, 2013, 97, 1, 36
- 74, The Epidemiology of Chronic Hepatitis C and One-Time Hepatitis C Virus Testing of Persons Born During 1945 to 1965 in the United States, Clinics in Liver Disease, 2013, 17, 1, 1
- 75, , , , , , , The Relative Efficacy of Boceprevir and Telaprevir in the Treatment of Hepatitis C Virus Genotype 1, Clinical Infectious Diseases, 2013, 56, 2, 228
- 76, , , Treating Chronic Hepatitis C Viral Infection: Rethinking Dose Reduction Strategies for PEG-IFN and Ribavirin in the Setting of New Direct Acting Agents, Current Hepatitis Reports, 2013, 12, 1, 13
- 77, , , , , , Treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for ‘middle’?, Journal of Gastroenterology, 2013, 48, 4, 555
- 78, Treatment of Hepatitis C: How Will We Use Viral Kinetics, Response-Guided Therapy?, Current Gastroenterology Reports, 2013, 15, 2
- 79, , , , Twelve week post-treatment undetectable hepatitis C virus (HCV)-RNA by PCR assay predicts a sustained virological response to anti-HCV therapy independently from immunological status of the infected patients, Journal of Antimicrobial Chemotherapy, 2013, 68, 4, 974
- 80, , , Update on the Treatment of Patients With Non-Genotype 1 Hepatitis C Virus Infection, Clinical Infectious Diseases, 2013, 56, 9, 1294
- 81, , Viral Hepatitis: Review of Arthritic Complications and Therapy for Arthritis in the Presence of Active HBV/HCV, Current Rheumatology Reports, 2013, 15, 4
- 82, , , , , Virological response for recurrent hepatitis C improves long-term survival in liver transplant recipients, Transplant International, 2013, 26, 1Direct Link:
- 83
- 84, , , , 2013,
- You have free access to this content85, , A brief history of the treatment of viral hepatitis C, Clinical Liver Disease, 2012, 1, 1Direct Link:
- 86, , , , , , , , Antiviral Therapy for HCV-Associated Cryoglobulinemic Glomerulonephritis: Case Report and Review of the Literature, Kidney and Blood Pressure Research, 2012, 35, 6, 687
- 87, Approach to the Treatment-naïve Patient with HCV Genotype 1 Infection, Infectious Disease Clinics of North America, 2012, 26, 4, 893
- 88, , Back from the Future: Treating Hepatitis C Virus with Conventional Interferon, Journal of Clinical and Experimental Hepatology, 2012, 2, 1, 3
- 89, , Barriers to hepatitis C treatment, Liver International, 2012, 32,Direct Link:
- 90
- 91, , Care of the Cirrhotic Patient, Infectious Disease Clinics of North America, 2012, 26, 4, 979
- 92, Challenges in the treatment of chronic hepatitis C in the HIV/HCV-coinfected patient, Expert Review of Anti-infective Therapy, 2012, 10, 10, 1117
- 93, , , , , , , , Clinical utility of the ARCHITECT HCV Ag assay for early treatment monitoring in patients with chronic hepatitis C genotype 1 infection, Journal of Clinical Virology, 2012, 55, 1, 17
- 94, Comparison of Efficacy of Peginterferon and Ribavirin Combination Therapy for Chronic Hepatitis C among Korean, Caucasian and Other Asians, The Korean Journal of Gastroenterology, 2012, 60, 5, 273
- 95, , , , , , Concurrent group treatment for hepatitis C: Implementation and outcomes in a methadone maintenance treatment program, Journal of Substance Abuse Treatment, 2012, 43, 4, 424
- 96, , , , Cost-effectiveness and Population Outcomes of General Population Screening for Hepatitis C, Clinical Infectious Diseases, 2012, 54, 9, 1259
- 97, , , , , , , , , , , Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis C, Hepatology, 2012, 56, 3Direct Link:
- 98, , , , , , , , , , , , , , , , , , , , , , Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial, The Lancet Infectious Diseases, 2012, 12, 9, 671
- 99, , , Despite poor interferon response in advanced hepatitis C virus infection, models of protease inhibitor treatment predict maximum treatment benefit, Alimentary Pharmacology & Therapeutics, 2012, 36, 7Direct Link:
- 100, , , , , , , , Development and Validation of a Simple, Rapid and Inexpensive PCR-RFLP Method for Genotyping of Common IL28B Polymorphisms: A Useful Pharmacogenetic Tool for Prediction of Hepatitis C Treatment Response, Hepatitis Monthly, 2012, 12, 3, 190
- 101
- 102, Editorial: Hepatitis C virus–related cryoglobulinemic vasculitis: Emerging trends in therapy, Arthritis & Rheumatism, 2012, 64, 3Direct Link:
- 103
- 104, , , , , , , , , Estimates of HCV-1 Patients Attaining RVR Following Dual Therapy with Peg-Interferon and Ribavirin, Digestive Diseases and Sciences, 2012,
- 105, , , , , Failure of Intravenous Silibinin Monotherapy to Prevent Hepatitis C Genotype 2A Liver Graft Reinfection, Hepatitis Monthly, 2012, 12, 6, 411
- 106
- 107
- 108, , , , , , , , , , , , , , , , , , , , , , , , , , Future research and collaboration: the “SINERGIE” project on HCV (South Italian Network for Rational Guidelines and International Epidemiology), BMC Infectious Diseases, 2012, 12, Suppl 2, S9
- 109, , GS-7977: a promising nucleotide analog NS5B polymerase inhibitor of HCV, Future Virology, 2012, 7, 6, 537
- 110, Hepatitis C Treatment Highlights From the 2011 American Association for the Study of Liver Disease Meeting, Clinical Infectious Diseases, 2012, 55, 3, 418
- You have free access to this content111, , Hepatitis C viral infection in patients with chronic kidney disease, Clinical Liver Disease, 2012, 1, 3Direct Link:
- You have free access to this content112, , Hepatitis C viral infection in patients with cirrhosis, Clinical Liver Disease, 2012, 1, 3Direct Link:
- 113, , , Hepatitis C Virus Prevention, Care, and Treatment: From Policy to Practice, Clinical Infectious Diseases, 2012, 55, suppl 1, S58
- 114, , Hepatitis C virus treatment and liver transplantation in the era of new antiviral therapies, Current Opinion in Organ Transplantation, 2012, 17, 3, 216
- 115, Hepatitis C Virus, Cryoglobulinemia, and Kidney: Novel Evidence, Scientifica, 2012, 2012, 1
- 116, , , , , , , , , , , Hepatitis C Virus: A Critical Appraisal of New Approaches to Therapy, Hepatitis Research and Treatment, 2012, 2012, 1
- 117, , , , Hepatitis C Virus: The Rising Concerns and Growing Hopes, Report From the HCV Symposium, Fourth Tehran Hepatitis Congress, november 2011, Tehran, Iran, Hepatitis Monthly, 2012, 12, 7, 423
- 118, , , , Hepatitis crónica por virus de la hepatitis C. Historia natural y tratamiento, Medicine - Programa de Formación Médica Continuada Acreditado, 2012, 11, 9, 529
- 119, , , , , , , , , , , , , , , , High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials, Hepatology, 2012, 56, 6Direct Link:
- 120, , HIV and viral hepatitis C coinfection in people who inject drugs, Current Opinion in HIV and AIDS, 2012, 7, 4, 339
- 121, , IL28B Polymorphisms as a Pretreatment Predictor of Response to HCV Treatment, Infectious Disease Clinics of North America, 2012, 26, 4, 863
- 122, , , Indicaciones actuales de tratamiento triple para la hepatitis C, Gastroenterología y Hepatología, 2012, 35, 4, 266
- 123, , Initial implementation and evaluation of a Hepatitis C treatment clinical decision support system (CDSS), Applied Clinical Informatics, 2012, 3, 3, 337
- 124, , , , , Interferon Responsiveness Does Not Change in Treatment-Experienced Hepatitis C Subjects: Implications for Drug Development and Clinical Decisions, Clinical Infectious Diseases, 2012, 55, 5, 639
- 125, , Is IL28B genotype associated with more than one aspect of viral clearance?, Hepatology, 2012, 56, 6Direct Link:
- You have free access to this content126, , Is there still a role for liver biopsy in managing hepatitis C virus infections?, Clinical Liver Disease, 2012, 1, 2Direct Link:
- 127, , Liver Biopsy Has a Low Diagnostic Performance for Intermediate Stages of Fibrosis, Clinical Gastroenterology and Hepatology, 2012, 10, 12, 1420
- 128, , Management of hepatitis C in HIV and/or HBV co-infected patients, Best Practice & Research Clinical Gastroenterology, 2012, 26, 4, 517
- 129, , Maximizing Opportunities and Avoiding Mistakes in Triple Therapy for Hepatitis C Virus, Gastroenterology, 2012, 142, 6, 1314
- 130, , , , , Meta-analysis: amantadine may lower the efficacy of pegylated interferon plus ribavirin in treatment-naive hepatitis C genotype 1 patients, International Journal of Infectious Diseases, 2012, 16, 10, e748
- 131, , , , , , , , NASPGHAN Practice Guidelines, Journal of Pediatric Gastroenterology and Nutrition, 2012, 54, 6, 838
- 132, , Natural history of acute and chronic hepatitis C, Best Practice & Research Clinical Gastroenterology, 2012, 26, 4, 401
- 133, , , New hepatitis C virus drug discovery strategies and model systems, Expert Opinion on Drug Discovery, 2012, 7, 9, 849
- 134, , New Pharmacotherapy for Hepatitis C, Clinical Pharmacology & Therapeutics, 2012, 92, 3, 294
- 135, , , New Virologic Tools for Management of Chronic Hepatitis B and C, Gastroenterology, 2012, 142, 6, 1303
- 136, Noninvasive Methods to Assess Liver Disease in Patients With Hepatitis B or C, Gastroenterology, 2012, 142, 6, 1293
- 137, , , , , , , , Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 2, 1095
- 138, , , , , , , , , , , , , Peginterferon alpha-2a and ribavirin in patients with hepatitis C virus genotype 1 infection with persistently normal alanine aminotransferase levels, Journal of Gastroenterology and Hepatology, 2012, 27, 11Direct Link:
- 139, , , , , Pegylated interferon-associated retinopathy is frequent in hepatitis C virus patients with hypertension and justifies ophthalmologic screening, Hepatology, 2012, 56, 2Direct Link:
- 140, , , , , , Peripheral blood cytopaenia limiting initiation of treatment in chronic hepatitis C patients otherwise eligible for antiviral therapy, Liver International, 2012, 32, 7Direct Link:
- 141, , , Pharmacogenomics of hepatitis C infections: personalizing therapy, Genome Medicine, 2012, 4, 12, 99
- 142, Predictors of response to chronic hepatitis C treatment, Future Virology, 2012, 7, 11, 1089
- 143, , , , , , , , , , , , , , , , , Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1, New England Journal of Medicine, 2012, 366, 3, 216
- 144, , , Prise en charge de l’hépatite C chronique : les dernières avancées thérapeutiques, Le Pharmacien Hospitalier et Clinicien, 2012,
- 145, Protease inhibitors for the treatment of chronic hepatitis C genotype-1 infection: the new standard of care, The Lancet Infectious Diseases, 2012, 12, 9, 717
- 146, , , Randomised clinical trial: pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-naïve patients with chronic hepatitis C genotype 1, Alimentary Pharmacology & Therapeutics, 2012, 36, 4Direct Link:
- 147, , Reactivation of hepatitis B virus and hepatitis C virus in patients with cancer, Nature Reviews Clinical Oncology, 2012, 9, 3, 156
- 148, , , , Recent trends in the treatment of chronic hepatitis C, The Korean Journal of Hepatology, 2012, 18, 1, 22
- 149, , , , , Recomendações para a terapêutica da hepatite C, GE Jornal Português de Gastrenterologia, 2012, 19, 3, 133
- 150, , , , , , Recommendations for standardized nomenclature and definitions of viral response in trials of hepatitis C virus investigational agents, Hepatology, 2012, 56, 6Direct Link:
- 151, , , , , , , , , , , , , , , , Refinement of stopping rules during treatment of hepatitis C genotype 1 infection with boceprevir and peginterferon/ribavirin, Hepatology, 2012, 56, 2Direct Link:
- 152, , , , , , , , , , , Safety profile of standard- vs. high-dose peginterferon alfa-2a plus standard-dose ribavirin in HCV genotype 1/4 patients: pooled analysis from 5 randomized studies, Expert Opinion on Drug Safety, 2012, 11, 6, 901
- 153, , Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein, Virus Research, 2012, 170, 1-2, 1
- 154
- 155, Surgical Clearance for the Patient with Chronic Liver Disease, Clinics in Liver Disease, 2012, 16, 2, 421
- 156, , , , , , , , , , , , , , , , , , , , , , , , Sustained Virological Response to Interferon Plus Ribavirin Reduces Non-Liver-Related Mortality in Patients Coinfected With HIV and Hepatitis C Virus, Clinical Infectious Diseases, 2012, 55, 5, 728
- 157, , , , , , , , , , , , , , , , , , , Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 8, 2866
- 158
- 159, , , Telaprevir for retreatment of HCV infection: review of the REALIZE trial, Future Virology, 2012, 7, 5, 435
- 160, , , , , , , Telaprevir-based triple therapy in liver transplant patients with hepatitis C virus: A 12-week pilot study providing safety and efficacy data, Liver Transplantation, 2012, 18, 12Direct Link:
- 161, , Telaprevir: A Hepatitis C NS3/4A Protease Inhibitor, Clinical Therapeutics, 2012, 34, 9, 1857
- 162, , , , , The high comorbidity burden of the hepatitis C virus infected population in the United States, BMC Infectious Diseases, 2012, 12, 1, 86
- 163, , The Importance of Rapid Viral Suppression in the Era of Directly Acting Antiviral Therapy for Hepatitis C Virus, Infectious Disease Clinics of North America, 2012, 26, 4, 879
- You have free access to this content164, , The new standard of HCV therapy: Retreatment in experienced patients, Clinical Liver Disease, 2012, 1, 1Direct Link:
- You have free access to this content165, , The new standard of HCV therapy: Treatment in therapy-naive patients , Clinical Liver Disease, 2012, 1, 1Direct Link:
- 166, , , , The Place of Immunotherapy in the Management of HCV-Induced Vasculitis: An Update, Clinical and Developmental Immunology, 2012, 2012, 1
- 167
- 168, , , , , , , , , , , , , , , Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon-alpha-2b and ribavirin combination therapy, Hepatology Research, 2012, 42, 10Direct Link:
- 169
- 170, , Treatment of patients with genotype 3 chronic hepatitis C- current and future therapies, Liver International, 2012, 32,Direct Link:
- 171, , Treatment of Patients With HCV Related Cirrhosis: Many Rewards With Very Few Risks, Hepatitis Monthly, 2012, 12, 6, 361
- 172, , Triple therapy with boceprevir or telaprevir for treatment naïve HCV patients, Best Practice & Research Clinical Gastroenterology, 2012, 26, 4, 445
- 173, Understanding the Role of PNPLA3 Genetic Variants in Patients with Chronic Hepatitis C Infection, Digestive Diseases and Sciences, 2012, 57, 8, 1977
- 174, , , , , , , Update on the Management and Treatment of Hepatitis C Virus Infection: Recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office, The American Journal of Gastroenterology, 2012, 107, 5, 669
- 175, , Utilizing genomic polymorphisms to personalize hepatitis C therapies, Current Opinion in Organ Transplantation, 2012, 17, 2, 198
- 176, , Virology of hepatitis C virus infection, Best Practice & Research Clinical Gastroenterology, 2012, 26, 4, 381
- 177, , , , Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus, Nature Biotechnology, 2011, 29, 11, 993
- 178, Hepatitis C therapy in 2011: is less more, is more less?, The Brazilian Journal of Infectious Diseases, 2011, 15, 6, 508
- 179, , IL28B polymorphism,Explanation for Different Responses to Therapy in Hepatitis C Patients, Hepatitis Monthly, 2011, 11, 12, 958

1527-3350/asset/olbannerleft.gif?v=1&s=4b2409f9534ed500d3c8da1940a23842e2b9932d)
1527-3350/asset/olbannerright.gif?v=1&s=141b9a8485298533c3e2016e937b0404f7d933e1)
