These authors contributed equally to this study.
Version of Record online: 30 JAN 2012
Copyright © 2011 American Association for the Study of Liver Diseases
Volume 55, Issue 3, pages 685–694, March 2012
How to Cite
Lütgehetmann, M., Mancke, L. V., Volz, T., Helbig, M., Allweiss, L., Bornscheuer, T., Pollok, J. M., Lohse, A. W., Petersen, J., Urban, S. and Dandri, M. (2012), Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation. Hepatology, 55: 685–694. doi: 10.1002/hep.24758
Potential conflict of interest: Nothing to report.
Supported by the Bundesministerium für Bildung und Forschung (BMBF), Innovative Therapieverfahren, Contract grant number: 01GU0702. M.D. is supported by the Deutsche Forschungsgemeinschaft (SFB 481; DA 1063/2-1). M.L. is supported by the Deutsche Forschungsgemeinschaft (LU 1707/1-1).
- Issue online: 23 FEB 2012
- Version of Record online: 30 JAN 2012
- Accepted manuscript online: 26 OCT 2011 11:10AM EST
- Manuscript Accepted: 4 OCT 2011
- Manuscript Received: 1 JUN 2011
Additional Supporting Information may be found in the online version of this article.
|HEP_24758_sm_SuppFig1.tif||5368K||Supporting Information Figure 1. Low cell proliferation rates and absence of significant cell death are observed in HBV/HDV infected human hepatocytes. Double staining using PCNA and human-specific CK-18 antibodies was performed to visualize human hepatocytes (pink) undergoing cell division (dark nuclei, indicated by arrows) in mice sacrificed either after 4 weeks (A) or 8 weeks (B) of co-infection. C, No signs of cell death were determined in human hepatocytes in the liver of mice sacrificed after 8 weeks of HBV/HDV infection using the TUNEL assay (green nuclei) and human specific CK18 staining (red cells). Nuclei were labelled with DAPI (blue) to identify individual cells; D, TUNEL positive control was obtained by treating serial frozen liver section from the same mouse used in C with DNAse I.|
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