SEARCH

SEARCH BY CITATION

References

  • 1
    Gómez-Lechón MJ, Donato MT, Castell JV, Jover R. Human hepatocytes as a tool for studying toxicity and drug metabolism. Curr Drug Metab 2003; 4: 292-312.
  • 2
    Hewitt NJ, Lechon MJG, Houston JB, Hallifax D, Brown HS, Maurel P, et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. In: 1st Medicon Valley Hepatocyte User Form Symposium; 2006 Jan 26-27; Copenhagen, Denmark: Taylor & Francis Inc.; 2006: 159-234.
  • 3
    Miranda JP, Leite SB, Muller-Vieira U, Rodrigues A, Carrondo MJT, Alves PM. Towards an extended functional hepatocyte in vitro culture. Tissue Eng Part C Methods 2009; 15: 157-167.
  • 4
    Wu F, Friend J, Remmel R, Cerra F, Hu W. Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids. Cell Transplant 1999; 8: 233-246.
  • 5
    Abu-Absi SF, Friend JR, Hansen LK, Hu WS. Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. Exp Cell Res 2002; 274: 56-67.
  • 6
    Dvir-Ginzberg M, Elkayam T, Aflalo ED, Agbaria R, Cohen S. Ultrastructural and functional investigations of adult hepatocyte spheroids during in vitro cultivation. Tissue Eng 2004; 10: 1806-1817.
  • 7
    Goral VN, Hsieh YC, Petzold ON, Clark JS, Yuen PK, Faris RA. Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants. Lab Chip 2010; 10: 3380-3386.
  • 8
    Nishimura M, Hagi M, Ejiri Y, Kishimoto S, Horie T, Narimatsu S, Naito S. Secretion of albumin and Induction of CYP1A2 and CYP3A4 in novel three-dimensional culture system for human hepatocytes using micro-space plate. Drug Metab Pharmacokinet 2010; 25: 236-242.
  • 9
    Domansky K, Inman W, Serdy J, Dash A, Lim MHM, Griffith LG. Perfused multiwell plate for 3D liver tissue engineering. Lab Chip 2010; 10: 51-58.
  • 10
    Khetani SR, Bhatia SN. Microscale culture of human liver cells for drug development. Nat Biotechnol 2008; 26: 120-126.
  • 11
    Carpentier B, Gautier A, Legallais C. Artificial and bioartificial liver devices: present and future. Gut 2009; 58: 1690-1702.
  • 12
    Zeilinger K, Schreiter T, Darnell M, Söderdahl T, Lübberstedt M, Dillner B, et al. Scaling down of a clinical 3D perfusion multi-compartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies. Tissue Eng Part C Methods 2011; 17: 549-556.
  • 13
    LeCluyse EL. Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur J Pharmaceut Sci 2001; 13: 343-368.
  • 14
    Tostões R, Leite S, Miranda J, Sousa M, Wang D, Carrondo M, Alves P. Perfusion of 3D encapsulated hepatocytes—a synergistic effect enhancing long-term functionality in bioreactors. Biotechnol Bioeng 2011: 41-49.
  • 15
    Castell JV, Gómez-Lechón MJ. In Vitro Methods in Pharmaceutical Research. San Diego, CA: Academic Press; 1997:ix.
  • 16
    Curcio E, Salerno S, Barbieri G, De Bartolo L, Drioli E, Bader A. Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system. Biomaterials 2007; 28: 5487-5497.
  • 17
    Glicklis R, Merchuk JC, Cohen S. Modeling mass transfer in hepatocyte spheroids via cell viability, spheroid size, and hepatocellular functions. Biotechnol Bioeng 2004; 86: 672-680.
  • 18
    Waxman DJ, Chang TK. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. Methods Mol Biol 2006; 320: 153-156.
  • 19
    Dunn JCY, Tompkins RG, Yarmush ML. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog 1991; 7: 237-245.
  • 20
    Wu FJ, Friend JR, Hsiao CC, Zilliox MJ, Ko WJ, Cerra FB, Hu WS. Efficient assembly of rat hepatocyte spheroids for tissue engineering applications. Biotechnol Bioeng 1996; 50: 404-415.
  • 21
    Foy BD, Rotem A, Toner M, Tompkins RG, Yarmush ML. A device to measure the oxygen-uptake rate of attached cells: importance in bioartificial organ design. Cell Transplant 1994; 3: 515-527.
  • 22
    Kidambi S, Yarmush RS, Novik E, Chao P, Yarmush ML, Nahmias Y. Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. Proc Natl Acad Sci U S A 2009; 106: 15714-15719.
  • 23
    Leite SB, Teixeira AP, Miranda JP, Tostões RM, Clemente JJ, Sousa MF, et al. Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: improved in vitro models for toxicological applications. Toxicol In Vitro 2011; 25: 825-832.
  • 24
    Kidambi S, Yarmush RS, Novik E, Chao P, Yarmush ML, Nahmias Y. Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. Proc Natl Acad Sci U S A 2009; 106: 15714-15719.
  • 25
    Jungermann K, Kietzmann T. Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver. Kidney Int 1997; 51: 402-412.
  • 26
    Brophy CM, Luebke-Wheeler JL, Amiot BP, Khan H, Remmel RP, Rinaldo P, Nyberg SL. Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function. HEPATOLOGY 2009; 49: 578-586.
  • 27
    Khaoustov VI, Darlington GJ, Soriano HE, Krishnan B, Risin D, Pellis NR, Yoffe B. Induction of three-dimensional assembly of human liver cells by simulated microgravity. In Vitro Cell Dev Biol Anim 1999; 35: 501-509.
  • 28
    Ponsoda X, Pareja E, Gómez-Lechón MJ, Fabra R, Carrasco E, Trullenque R, Castell JV. Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor. J Hepatol 2001; 34: 19-25.
  • 29
    Schmelzer E, Mutig K, Schrade P, Bachmann S, Gerlach JC, Zeilinger K. Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support. Biotechnol Bioeng 2009; 103: 817-827.
  • 30
    Katz NR. Metabolic heterogeneity of hepatocytes across the liver acinus. J Nutr 1992; 122: 843-849.