Hepatobiliary Malignancies

You have full text access to this OnlineOpen article

Family history of liver cancer and hepatocellular carcinoma†

  1. Federica Turati1,2,
  2. Valeria Edefonti2,
  3. Renato Talamini3,
  4. Monica Ferraroni2,
  5. Matteo Malvezzi1,2,4,
  6. Francesca Bravi1,2,
  7. Silvia Franceschi5,
  8. Maurizio Montella6,
  9. Jerry Polesel3,
  10. Antonella Zucchetto3,
  11. Carlo La Vecchia1,2,7,‡,*,
  12. Eva Negri1,
  13. Adriano Decarli2,4

Article first published online: 21 MAR 2012

DOI: 10.1002/hep.24794

Issue

Hepatology

Hepatology

Volume 55, Issue 5, pages 1416–1425, May 2012

Additional Information

How to Cite

Turati, F., Edefonti, V., Talamini, R., Ferraroni, M., Malvezzi, M., Bravi, F., Franceschi, S., Montella, M., Polesel, J., Zucchetto, A., La Vecchia, C., Negri, E. and Decarli, A. (2012), Family history of liver cancer and hepatocellular carcinoma. Hepatology, 55: 1416–1425. doi: 10.1002/hep.24794

Author Information

  1. 1

    Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy

  2. 2

    Dipartimento di Medicina del Lavoro, Sezione di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy

  3. 3

    S.O.C. di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (Pordenone), Italy

  4. 4

    Struttura Complessa di Statistica Medica, Biometria e Bioinformatica, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

  5. 5

    International Agency for Research on Cancer, Lyon, France

  6. 6

    Unità di Epidemiologia, Istituto Tumori “Fondazione Pascale”, IRCCS, Naples, Italy

  7. 7

    International Prevention Research Institute (IPRI), Lyon, France

  1. ‡

    fax: +39 0233200231

*Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche “Mario Negri”, Via La Masa 19, 20156 Milan, Italy

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    fax: +39 0233200231

Publication History

  1. Issue published online: 19 APR 2012
  2. Article first published online: 21 MAR 2012
  3. Accepted manuscript online: 16 NOV 2011 07:46AM EST
  4. Manuscript Accepted: 27 OCT 2011
  5. Manuscript Received: 18 JUL 2011

Funded by

  • Italian Association for Cancer Research (AIRC; Milan, Italy). Grant Number: 10068)
  • Italian League Against Cancer. Grant Number: (project: 11/2008—“Sindromi ereditarie e rischio di neoplasie comuni in Italia”)
  • The Italian Ministry of Education. Grant Number: PRIN2009 × 84CBN

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (985K)

Abstract

Familial clustering of hepatocellular carcinoma (HCC) has been frequently reported in eastern Asiatic countries, where hepatitis B infection is common. Little is known about the relationship between family history of liver cancer and HCC in Western populations. We carried out a case-control study in Italy, involving 229 HCC cases and 431 hospital controls. Data on family history were summarized through a binary indicator (yes/no) and a family history score (FHscore), considering selected family characteristics. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from unconditional multiple logistic regression models, including terms for age, sex, study center, education, tobacco smoking, alcohol drinking, hepatitis B surface antigen, and/or anti–hepatitis C virus positivity. We also performed a meta-analysis on family history of liver cancer and liver cancer updated to April 2011 using random-effects models. After adjustment for chronic infection with hepatitis B/C viruses, family history of liver cancer was associated with HCC risk, when using both the binary indicator (OR, 2.38; 95% CI, 1.01-5.58) and the FHscore, with increasing ORs for successive score categories. Compared to subjects without family history and no chronic infection with hepatitis B/C viruses, the OR for those exposed to both risk factors was 72.48 (95% CI, 21.92-239.73). In the meta-analysis, based on nine case-control and four cohort studies, for a total of approximately 3,600 liver cancer cases, the pooled relative risk for family history of liver cancer was 2.50 (95% CI, 2.06-3.03). Conclusion: A family history of liver cancer increases HCC risk, independently of hepatitis. The combination of family history of liver cancer and hepatitis B/C serum markers is associated with an over 70-fold elevated HCC risk. (HEPATOLOGY 2011)

View Full Article (HTML) Get PDF (985K)