• 1
    Jansen PL, Strautnieks SS, Jacquemin E, Hadchouel M, Sokal EM, Hooiveld GJ, et al. Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. Gastroenterology 1999; 117: 1370-1379.
  • 2
    Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet 1998; 20: 233-238.
  • 3
    Strautnieks SS, Byrne JA, Pawlikowska L, Cebecauerova D, Rayner A, Dutton L, et al. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology 2008; 134: 1203-1214.
  • 4
    Kipp H, Pichetshote N, Arias IM. Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver. J Biol Chem 2001; 276: 7218-7224.
  • 5
    Kipp H, Arias IM. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J Biol Chem 2000; 275: 15917-15925.
  • 6
    Wakabayashi Y, Lippincott-Schwartz J, Arias IM. Intracellular trafficking of bile salt export pump (ABCB11) in polarized hepatic cells: constitutive cycling between the canalicular membrane and rab11-positive endosomes. Mol Biol Cell 2004; 15: 3485-3496.
  • 7
    Crocenzi FA, Mottino AD, Cao J, Veggi LM, Pozzi EJ, Vore M, et al. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Am J Physiol Gastrointest Liver Physiol 2003; 285: G449-G459.
  • 8
    Crocenzi FA, Sanchez Pozzi EJ, Ruiz ML, Zucchetti AE, Roma MG, et al. Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat. HEPATOLOGY 2008; 48: 1885-1895.
  • 9
    Elferink MG, Olinga P, Draaisma AL, Merema MT, Faber KN, Slooff MJ, et al. LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am J Physiol Gastrointest Liver Physiol 2004; 287: G1008-G1016.
  • 10
    Ortiz DF, Moseley J, Calderon G, Swift AL, Li S, Arias IM. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. J Biol Chem 2004; 279: 32761-32770.
  • 11
    Rahner C, Stieger B, Landmann L. Apical endocytosis in rat hepatocytes in situ involves clathrin, traverses a subapical compartment, and leads to lysosomes. Gastroenterology 2000; 119: 1692-1707.
  • 12
    Boll W, Rapoport I, Brunner C, Modis Y, Prehn S, Kirchhausen T. The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppO sorting signals at distinct sites. Traffic 2002; 3: 590-600.
  • 13
    Colgan L, Liu H, Huang SY, Liu YJ. Dileucine motif is sufficient for internalization and synaptic vesicle targeting of vesicular acetylcholine transporter. Traffic 2007; 8: 512-522.
  • 14
    Hu W, Howard M, Lukacs GL. Multiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulator. Biochem J 2001; 354: 561-572.
  • 15
    Peter K, Varga K, Bebok Z, McNicholas-Bevensee CM, Schwiebert L, Sorscher EJ, et al. Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression. J Biol Chem 2002; 277: 49952-49957.
  • 16
    Wu H, Windmiller DA, Wang L, Backer JM. YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals. J Biol Chem 2003; 278: 40425-40428.
  • 17
    Dittrich E, Haft CR, Muys L, Heinrich PC, Graeve L. A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. J Biol Chem 1996; 271: 5487-5494.
  • 18
    Jockers R, Angers S, Da Silva A, Benaroch P, Strosberg AD, Bouvier M, et al. Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis. J Biol Chem 1999; 274: 28900-28908.
  • 19
    Ribeiro FM, Black SA, Cregan SP, Prado VF, Prado MA, Rylett RJ, et al. Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. J Neurochem 2005; 94: 86-96.
  • 20
    Harter C, Mellman I. Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membrane. J Cell Biol 1992; 117: 311-325.
  • 21
    Yokode M, Pathak RK, Hammer RE, Brown MS, Goldstein JL, Anderson RG. Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice. J Cell Biol 1992; 117: 39-46.
  • 22
    Obermuller S, Kiecke C, von Figura K, Honing S. The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes. J Cell Sci 2002; 115: 185-194.
  • 23
    Bairstow SF, Ling K, Su X, Firestone AJ, Carbonara C, Anderson RA. Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis. J Biol Chem 2006; 281: 20632-20642.
  • 24
    Chen WJ, Goldstein JL, Brown MS. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J Biol Chem 1990; 265: 3116-3123.
  • 25
    Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell 2002; 109: 523-535.
  • 26
    Kittler JT, Chen G, Honing S, Bogdanov Y, McAinsh K, Arancibia-Carcamo IL, et al. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A 2005; 102: 14871-14876.
  • 27
    Owen DJ, Evans PR. A structural explanation for the recognition of tyrosine-based endocytotic signals. Science 1998; 282: 1327-1332.
  • 28
    Prince LS, Peter K, Hatton SR, Zaliauskiene L, Cotlin LF, Clancy JP, et al. Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal. J Biol Chem 1999; 274: 3602-3609.
  • 29
    Tsudo M, Kozak RW, Goldman CK, Waldmann TA. Contribution of a p75 interleukin 2 binding peptide to a high-affinity interleukin 2 receptor complex. Proc Natl Acad Sci U S A 1987; 84: 4215-4218.
  • 30
    Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL. Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases. Am J Physiol Cell Physiol 2007; 293: C1709-C1716.
  • 31
    Nishimura N, Sasaki T. Cell-surface biotinylation to study endocytosis and recycling of occludin. Methods Mol Biol 2008; 440: 89-96.
  • 32
    Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, et al. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 1992; 70: 715-728.
  • 33
    Zerial M, McBride H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2001; 2: 107-117.
  • 34
    Sharma DK, Choudhury A, Singh RD, Wheatley CL, Marks DL, Pagano RE. Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for recycling. J Biol Chem 2003; 278: 7564-7572.
  • 35
    Hill E, van Der Kaay J, Downes CP, Smythe E. The role of dynamin and its binding partners in coated pit invagination and scission. J Cell Biol 2001; 152: 309-323.
  • 36
    Sever S, Damke H, Schmid SL. Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J Cell Biol 2000; 150: 1137-1148.
  • 37
    Knisely AS, Strautnieks SS, Meier Y, Stieger B, Byrne JA, Portmann BC, et al. Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency. HEPATOLOGY 2006; 44: 478-486.
  • 38
    Jackson AP, Flett A, Smythe C, Hufton L, Wettey FR, Smythe E. Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase. J Cell Biol 2003; 163: 231-236.
  • 39
    Weixel KM, Bradbury NA. Mu 2 binding directs the cystic fibrosis transmembrane conductance regulator to the clathrin-mediated endocytic pathway. J Biol Chem 2001; 276: 46251-46259.
  • 40
    Currier SJ, Ueda K, Willingham MC, Pastan I, Gottesman MM. Deletion and insertion mutants of the multidrug transporter. J Biol Chem 1989; 264: 14376-14381.
  • 41
    Kagawa T, Watanabe N, Mochizuki K, Numari A, Ikeno Y, Itoh J, et al. Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells. Am J Physiol Gastrointest Liver Physiol 2008; 294: G58-G67.
  • 42
    Crocenzi FA, Mottino AD, Sanchez Pozzi EJ, Pellegrino JM, Rodriguez Garay EA, Milkiewicz P, et al. Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat. Gut 2003; 52: 1170-1177.
  • 43
    Roman ID, Fernandez-Moreno MD, Fueyo JA, Roma MG, Coleman R. Cyclosporin A induced internalization of the bile salt export pump in isolated rat hepatocyte couplets. Toxicol Sci 2003; 71: 276-281.
  • 44
    Hayashi H, Sugiyama Y. 4-Phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps. HEPATOLOGY 2007; 45: 1506-1516.
  • 45
    Hayashi H, Sugiyama Y. Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11). Mol Pharmacol 2009; 75: 143-150.
  • 46
    Ismair MG, Hausler S, Stuermer CA, Guyot C, Meier PJ, Roth J, et al. ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes. HEPATOLOGY 2009; 49: 1673-1682.
  • 47
    Henley JR, Krueger EW, Oswald BJ, McNiven MA. Dynamin-mediated internalization of caveolae. J Cell Biol 1998; 141: 85-99.
  • 48
    Moreno M, Molina H, Amigo L, Zanlungo S, Arrese M, Rigotti A, et al. Hepatic overexpression of caveolins increases bile salt secretion in mice. HEPATOLOGY 2003; 38: 1477-1488.
  • 49
    Paulusma CC, de Waart DR, Kunne C, Mok KS, Elferink RP. Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content. J Biol Chem 2009; 284: 9947-9954.