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HEP_25561_sm_suppinfofig.tif5844KSupporting Information Figure: Western blot analyses demonstrate reduced UGT1A (all UGT1A proteins using antibody directed against common sequence), UGT1A3, UGT1A4, UGT1A6 protein in the humanized tgUGT1A SNP mice. Note that the UGT1A and UGT1A6 antibodies used display cross-reactivity with mouse proteins. However, protein levels in htgUGT1A SNP mice are lower than in the wild type counterparts indicating lower UGT1A protein expression in the presence of UGT1A SNPs.

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