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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_25595_sm_SuppFig1.tif7676KSupplementary Figure 1. The different features of stroma in the different subtypes of Cholangiocellular carcinomas (CCs). (A) Hepatocytic differentiation area. (B) Ductular area. (C) Mucin-producing CC area.
HEP_25595_sm_SuppFig2.tif3194KSupplementary Figure 2. Gene expression profiling. Box-plots of RT-PCR results for hepatic progenitor cell (HPC)/biliary markers (KRT19/7,and EpCAM). Hilar bile duct (BD) (n=6), segmental BD (n=4), and ductular reaction (DR) (n=8).
HEP_25595_sm_SuppFig3.tif3566KSupplementary Figure 3. Gene expression profiling. Box-plots of RT-PCR results for hepatic progenitor cell (HPC)/biliary markers (KRT7, ANXA3, and TACSTD2). Hilar cholangiocellular carcinomas (Hilar CCs) (n=5), mucin-producing intrahepatic CCs (muc-ICCs) (n=6), ICC with mixed features (mixed-ICCs) (n=7), and cholangiolocellular carcinomas (CLCs) (n=7).
HEP_25595_sm_SuppFig4.tif5642KSupplementary Figure 4. The overall survival rate in patients with hilar cholangiocellular carcinomas (Hilar CCs), mucin-producing intrahepatic CCs (muc-ICCs), ICCs with mixed features (mixed-ICCs) and cholangiolocellular carcinomas (CLCs). Hilar CC and muc-ICC group tended to show worse prognosis compared with mixed-ICC and CLC group.
HEP_25595_sm_SuppTab.doc36KSupporting Information Tables
HEP_25595_sm_SuppInfo.doc72KSupporting Information

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