Steatohepatitis/Metabolic Liver Disease

Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice†‡

  1. Jiyoung Lee1,§,
  2. Sunmi Seok1,§,
  3. Pengfei Yu2,
  4. Kyungsu Kim2,
  5. Zachary Smith1,
  6. Marcelo Rivas-Astroza2,
  7. Sheng Zhong2,
  8. Jongsook Kim Kemper1,¶,*

Article first published online: 24 APR 2012

DOI: 10.1002/hep.25609

Additional Information

How to Cite

Lee, J., Seok, S., Yu, P., Kim, K., Smith, Z., Rivas-Astroza, M., Zhong, S. and Kemper, J. K. (2012), Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice. Hepatology. doi: 10.1002/hep.25609

Author Information

  1. 1

    Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL

  2. 2

    Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL

  1. §

    *These authors contributed equally to this study.

  2. fax: 217-333-1133.

*Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, MC-114, 407 South Goodwin Avenue, Urbana, IL 61801

  • †

    Potential conflict of interest: Nothing to report.

  • ‡

    This study was supported by the National Institutes of Health (grant no.: DK062777) and a Basic Science Award from the American Diabetes Association (to J.K.K.).

Publication History

  1. Article first published online: 24 APR 2012
  2. Accepted manuscript online: 25 JAN 2012 05:21AM EST
  3. Manuscript Accepted: 17 JAN 2012
  4. Manuscript Received: 1 DEC 2011

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