Steatohepatitis/Metabolic Liver Disease

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes†‡§

  1. Manal F. Abdelmalek1,¶,*,
  2. Mariana Lazo2,
  3. Alena Horska3,
  4. Susanne Bonekamp3,
  5. Edward W. Lipkin5,
  6. Ashok Balasubramanyam6,
  7. John P. Bantle7,
  8. Richard J. Johnson8,
  9. Anna Mae Diehl1,
  10. Jeanne M. Clark2,4,
  11. and the Fatty Liver Subgroup of the Look AHEAD Research Group2

Article first published online: 12 JUL 2012

DOI: 10.1002/hep.25741

Issue

Hepatology

Hepatology

Volume 56, Issue 3, pages 952–960, September 2012

Additional Information

How to Cite

Abdelmalek, M. F., Lazo, M., Horska, A., Bonekamp, S., Lipkin, E. W., Balasubramanyam, A., Bantle, J. P., Johnson, R. J., Diehl, A. M., Clark, J. M. and and the Fatty Liver Subgroup of the Look AHEAD Research Group (2012), Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology, 56: 952–960. doi: 10.1002/hep.25741

Author Information

  1. 1

    Division of Gastroenterology and Hepatology, Duke University, Durham, NC

  2. 2

    Department of Epidemiology, Johns Hopkins University, Baltimore, MD

  3. 3

    Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD

  4. 4

    Department of Medicine, Johns Hopkins University, Baltimore, MD

  5. 5

    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA

  6. 6

    Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX

  7. 7

    Division of Endocrinology and Diabetes, University of Minnesota, Minneapolis, MN

  8. 8

    Division of Nephrology, University of Colorado, Denver, CO

  1. fax: (919) 684-8857

*Division of Gastroenterology and Hepatology, Duke University Medical Center, P.O. Box 3913, Durham, NC 27710

  1. †

    Potential conflict of interest: R.J.J. published a lay book (“The Sugar Fix”) that discusses the potential role of fructose in obesity and fatty liver and has a patent application on lowering uric acid to reduce fatty liver disease.

  2. ‡

    The study was supported by the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disorders (NIH/NIDDK; grant nos.: RO1-DK060427 and UO1-DK57149) and the John Hopkins University School of Medicine General Clinical Research Center (M01-RR00052). R.J.J. is supported by grant HL-68607. M.F.A. is supported by a NIH/NIDDK K23 Career Development Award (K23-DK062116).

  3. §

    This study was presented at the American Association for the Study of Liver Diseases 60th Annual Meeting, Boston, MA, October 30-November 3, 2009.

  4. fax: (919) 684-8857

Publication History

  1. Issue published online: 28 AUG 2012
  2. Article first published online: 12 JUL 2012
  3. Accepted manuscript online: 29 MAR 2012 06:16AM EST
  4. Manuscript Accepted: 18 FEB 2012
  5. Manuscript Received: 17 OCT 2011

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (473K)

Options for accessing this content:

  • If you have access to this content through a society membership, please first log in to your society website.
  • If you would like institutional access to this content, please recommend the title to your librarian.
  • Login via other institutional login options http://onlinelibrary.wiley.com/login-options.
  • You can purchase online access to this Article for a 24-hour period (price varies by title)
    • If you already have a Wiley Online Library or Wiley InterScience user account: login above and proceed to purchase the article.
    • New Users: Please register, then proceed to purchase the article.

If your institution is a registered Wiley Online Library customer, you can log in under your institution's name to see our content. This access is provided by Shibboleth or Athens.

Type your institution's name in the box below. If your institution is a Wiley customer, it will appear in the list of suggested institutions.

Please register to:

  • Save publications, articles and searches
  • Get email alerts
  • Get all the benefits mentioned below!

Register now >

Get PDF (473K)