Liver Failure/Cirrhosis/Portal Hypertension

Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents†

  1. Yuko Kageyama1,2,
  2. Hitoshi Ikeda1,3,‡,*,
  3. Naoko Watanabe1,3,
  4. Masakazu Nagamine1,
  5. Yoshika Kusumoto1,
  6. Mitsuru Yashiro1,
  7. Yumiko Satoh1,
  8. Tatsuo Shimosawa1,
  9. Koji Shinozaki4,
  10. Tomoaki Tomiya3,
  11. Yukiko Inoue3,
  12. Takako Nishikawa3,
  13. Natsuko Ohtomo3,
  14. Yasushi Tanoue3,
  15. Hiromitsu Yokota1,
  16. Takatoshi Koyama2,
  17. Kazuhiro Ishimaru5,
  18. Yasuo Okamoto5,
  19. Yoh Takuwa5,
  20. Kazuhiko Koike3,
  21. Yutaka Yatomi1

Article first published online: 4 OCT 2012

DOI: 10.1002/hep.25780

Issue

Hepatology

Hepatology

Volume 56, Issue 4, pages 1427–1438, October 2012

Additional Information

How to Cite

Kageyama, Y., Ikeda, H., Watanabe, N., Nagamine, M., Kusumoto, Y., Yashiro, M., Satoh, Y., Shimosawa, T., Shinozaki, K., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., Yokota, H., Koyama, T., Ishimaru, K., Okamoto, Y., Takuwa, Y., Koike, K. and Yatomi, Y. (2012), Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents. Hepatology, 56: 1427–1438. doi: 10.1002/hep.25780

Author Information

  1. 1

    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

  2. 2

    Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan

  3. 3

    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

  4. 4

    Minase Research Institute Research Headquarters, Ono Pharmaceutical Co., Osaka, Japan

  5. 5

    Department of Physiology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan

  1. ‡

    fax: 81-3-5689-0495

*Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    fax: 81-3-5689-0495

Publication History

  1. Issue published online: 4 OCT 2012
  2. Article first published online: 4 OCT 2012
  3. Accepted manuscript online: 13 APR 2012 12:44PM EST
  4. Manuscript Accepted: 4 APR 2012
  5. Manuscript Received: 11 OCT 2011

Funded by

  • Ministry of Education, Culture, Sports, Science and Technology of Japan. Grant Number: KAKENHI 22590716 (to H.I.)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (1293K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Yoh Takuwa, Hitoshi Ikeda, Yasuo Okamoto, Noriko Takuwa, Kazuaki Yoshioka, Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013, 1831, 1, 185

    CrossRef

  2. 2
    Catherine O'Sullivan, Kumlesh K. Dev, The structure and function of the S1P1 receptor, Trends in Pharmacological Sciences, 2013,

    CrossRef

View Full Article (HTML) Get PDF (1293K)