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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_25789_sm_SuppFig1.tif1520KSupplemental Figure 1. Liver sections (x100 magnification) of mice after 30 weeks on a high-fat and high-cholesterol (HFHC) diet stained with hematoxylin and eosin showing severe steatosis with substantial mixed inflammatory infiltrate (arrows indicate inflammatory cell clusters).
HEP_25789_sm_SuppFig2.tif21468KSupplemental Figure 2. Liver sections (x200 magnification) of mice after 30 weeks on a high-fat and high-cholesterol (HFHC) diet stained with a. Sirius red, viewed under polarized; and b. Masson's trichrome and viewed under normal light. These sections show perisinusoidal, “chickenwire”, fibrosis (arrows) in association with severe steatosis. a. Sirius Red stain (polarized light), b. Masson's Trichrome stain
HEP_25789_sm_SuppFig2b.tif1593KSupporting Information Figure 2b.
HEP_25789_sm_SuppFig3.tif29760KSupplemental Figure 3. Liver sections (x200 magnification) of mice at three time points after the introduction of a high-fat and high-cholesterol (HFHC) diet and stained with hematoxylin and eosin, Masson's trichrome and Sirius red viewed polarized light. These sections demonstrate that although hepatic steatosis and inflammation develop by 8 and 12 weeks, hepatic fibrosis does not develop until 30 weeks after the introduction of the HFHC diet.
HEP_25789_sm_SuppTab1.doc39KSupplemental Table 1. Changes in body and liver weight, hepatic lipid composition and plasma levels over time after introduction of a HFHC diet.

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