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Liver Injury/Regeneration

Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice†

  1. Johan M. Waern1,2,3,
  2. Qinggong Yuan1,2,
  3. Urda Rüdrich1,2,
  4. Pablo D. Becker4,
  5. Kai Schulze4,
  6. Helene Strick-Marchand5,6,
  7. Nicholas D. Huntington5,6,
  8. Behrend J. Zacher1,
  9. Karsten Wursthorn1,
  10. James P. DiSanto5,6,
  11. Carlos A. Guzman4,
  12. Michael P. Manns1,
  13. Michael Ott1,2,‡,
  14. Michael Bock1,2,§,¶,*

Article first published online: 4 OCT 2012

DOI: 10.1002/hep.25816

Issue

Hepatology

Hepatology

Volume 56, Issue 4, pages 1479–1488, October 2012

Additional Information

How to Cite

Waern, J. M., Yuan, Q., Rüdrich, U., Becker, P. D., Schulze, K., Strick-Marchand, H., Huntington, N. D., Zacher, B. J., Wursthorn, K., DiSanto, J. P., Guzman, C. A., Manns, M. P., Ott, M. and Bock, M. (2012), Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice. Hepatology, 56: 1479–1488. doi: 10.1002/hep.25816

Author Information

  1. 1

    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

  2. 2

    Twincore, Centre for Experimental and Clinical Infection Research, Hannover, Germany

  3. 3

    Medical and Oncology Clinic, Södra Älvsborgs Sjukhus, Borås, Sweden

  4. 4

    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

  5. 5

    Innate Immunity Unit, Immunology Department, Institut Pasteur, Paris, France

  6. 6

    Institut National de la Santé et de la Recherche Médicale (INSERM) U668, Paris, France

  1. §

    These authors contributed equally to this work.

  2. fax: +49 511 532 165122

*Hepatic Cell Therapy, Cluster of Excellence REBIRTH, Dept. of Gastroenterology, Hepatology and Endocrinology, OE6810, Hannover Medical School, Carl-Neuberg-Str-1, 30625 Hannover, Germany

  1. †

    Potential conflict of interest: Nothing to report.

  2. §

    These authors contributed equally to this work.

  3. fax: +49 511 532 165122

Publication History

  1. Issue published online: 4 OCT 2012
  2. Article first published online: 4 OCT 2012
  3. Accepted manuscript online: 26 APR 2012 05:43AM EST
  4. Manuscript Accepted: 20 APR 2012
  5. Manuscript Received: 7 DEC 2011

Funded by

  • START-MSC2 program of the BMBF
  • M.O. supporting J.M.W.
  • GCGH-program GC4 (Bill and Melinda Gates Foundation) to J.D.S., C.A.G., M.P.M., and M.O.
  • REBIRTH Cluster of Excellence (Deutsche Forschungsgemeinschaft) to U.R., C.A.G., M.P.M., M.O., and M.B. Q.Y.
  • SFB 738 (Deutsche Forschungsgemeinschaft) awarded to M.O.

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