Additional Supporting Information may be found in the online version of this article.

HEP_25830_sm_SuppFig1.tif1329KSupporting figure 1 25(OH)-vitamin D concentrations and liver stiffness. Vitamin D concentrations are negatively correlated with liver stiffness, as determined by transient elastography (TE) (panel A). Vitamin D concentrations are also negatively correlated with stiffness in patients with TE < 20 kPa (panel B). Patients with increased liver stiffness (TE ≥ 7 kPa) display significantly lower 25(OH)-vitamin D levels as compared to patients with TE < 7 kPa (panel C).
HEP_25830_sm_SuppFig2.tif2025KSupporting figure 2 25(OH)-vitamin D levels are associated with sunlight hours. Sunshine hours in the region of Bonn at the time when patients were recruited (according to the database from the German Weather Service; are indicated by the orange and serum 25(OH)-vitamin D levels by the black line. Notably, 25(OH)-vitamin D concentrations are significantly (r = 0.450, p = 0.03) correlated to sunlight hours, albeit with a 4 to 6-week-delay. Of note, this correlation was also present when analyzing patients with TE < or ≥ 7 kPa separately (data not shown).
HEP_25830_sm_SuppFig3.tif931KSupporting figure 3 Liver stiffness in carriers of different CYP2R1 genotypes. With respect to the CYP2R1 variant, differences in stiffness values were neither observed for patients with TE values < nor ≥ 7 kPa.
HEP_25830_sm_SuppInfo.doc32KSupporting Information
HEP_25830_sm_SuppTables.doc31KSupporting Information

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