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Article first published online: 29 JUN 2012
Copyright © 2012 American Association for the Study of Liver Diseases
Volume 56, Issue 2, pages 567–575, August 2012
How to Cite
Jacobson, I. M., Marcellin, P., Zeuzem, S., Sulkowski, M. S., Esteban, R., Poordad, F., Bruno, S., Burroughs, M. H., Pedicone, L. D., Boparai, N., Deng, W., DiNubile, M. J., Gottesdiener, K. M., Brass, C. A., Albrecht, J. K. and Bronowicki, J.-P. (2012), Refinement of stopping rules during treatment of hepatitis C genotype 1 infection with boceprevir and peginterferon/ribavirin. Hepatology, 56: 567–575. doi: 10.1002/hep.25865
Potential conflict of interest: The Serine Protease Inhibitor Therapy 2 study (ClinicalTrials.gov identifier NCT00705432) and the Retreatment With HCV Serine Protease Inhibitor Boceprevir and Pegintron/Rebetol 2 study (ClinicalTrials.gov identifier NCT00708500) were funded by Schering-Plough/Merck. The trials were designed, managed, and analyzed by employees of the sponsor in conjunction with external academic investigators. Every coauthor of this article had full access to all pertinent data upon request. A penultimate version of this article was reviewed by the sponsor. Each coauthor approved an essentially final version of this article. The opinions expressed in this report represent the consensus of the authors and do not necessarily reflect the formal positions of Merck or the other institutions listed as investigator affiliations. Present and former employees of Merck may own stock or stock options in the company. All academic authors have been investigators for Schering-Plough/Merck. In addition, Ira M. Jacobson has received research support from Schering-Plough/Merck, Tibotec, Roche/Genentech, Pharmasset, Anadys, Boehringer-Ingelheim, Novartis, Gilead, Vertex, GlobeImmune, Idenix, Abbott, Zymogenetics, and Human Genome Sciences and has served as a consultant and/or speaker for Bristol-Myers Squibb, Novartis, Gilead, Schering-Plough/Merck, Pfizer, Vertex, GlobeImmune, Human Genome Sciences, Boehringer-Ingelheim, Pharmasset, Zymogenetics, Tibotec, Abbott, Roche/Genentech, Anadys, and Sanofi-Aventis. Patrick Marcellin has received grant support from Abbott, Bristol-Myers Squibb, Boehringer-Ingelheim, Echosens, Gilead, Janssen-Tibotec, Schering-Plough/Merck, Novartis, Roche, Pfizer, Pharmasset, GlaxoSmithKline and Vertex and has served as a consultant and/or speaker for Abbott, Bristol-Myers Squibb, Gilead, Janssen-Tibotec, Schering-Plough/Merck, Novartis, Roche, Pharmasset, and Vertex. Stefan Zeuzem has served as a consultant and/or speaker for Abbott, Achillion, Bristol-Myers Squibb, Boehringer-Ingelheim, Gilead, iTherX, Janssen-Cilag, Schering-Plough/Merck, Novartis, Roche, Santaris, Taussen-Tibotec, and Vertex. Mark S. Sulkowski has been a consultant for Schering-Plough/Merck, Abbott, Anadys, Boehringer Ingelheim Pharmaceuticals, Gilead, Pfizer, Human Genome Sciences, Roche, Taussen-Tibotec, and Vertex and has received grant support from Schering-Plough/Merck, Abbott, Boehringer Ingelheim Pharmaceuticals, Gilead, Bristol-Myers Squibb, Roche, Vertex, Tibotec, and Pharmasset. Rafael Esteban has served as a consultant and/or speaker for Schering-Plough/Merck. Fred Poordad has received research grants from Schering-Plough/Merck, Vertex, Genentech, Bristol-Myers Squibb, Gilead, Pfizer, Abbott, Tibotec, Idenix and Pharmasset, is a member of the speaker's bureau for Genentech and Gilead, and is an advisor/consultant for Schering-Plough/Merck, Vertex, Gilead, Genentech, and Abbott. Savino Bruno has served as a consultant and/or speaker for Schering-Plough/Merck, Bristol-Myers Squibb, and Roche. Jean-Pierre Bronowicki has served as a consultant and/or speaker for Schering-Plough/Merck, Roche, Gilead, Bristol-Myers-Squibb, Janssen, Boehringer-Ingelheim, Novartis, and Bayer and has received payments from Roche for expenses incurred by meeting attendance.
Navdeep Boparai is currently affiliated with Bristol-Myers Squibb (Hopewell, NJ); Keith M. Gottesdiener is currently affiliated with Rhythm Pharmaceuticals (Boston, MA); and Clifford A. Brass is currently affiliated with Novartis (Summit, NJ).
- Issue published online: 25 JUL 2012
- Article first published online: 29 JUN 2012
- Accepted manuscript online: 22 MAY 2012 11:26AM EST
- Manuscript Accepted: 16 MAY 2012
- Manuscript Received: 14 MAR 2012
- 10Resistance-associated variants in chronic hepatitis C patients treated with protease inhibitors. Curr Gastroenterol Rep 2012; 14: 47-54., .