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Liver Biology/Pathobiology

Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib†

  1. Carlo Spirli1,
  2. Carola M. Morell1,3,
  3. Luigi Locatelli1,3,
  4. Stefano Okolicsanyi1,3,
  5. Cecilia Ferrero1,
  6. Amy K. Kim1,
  7. Luca Fabris2,
  8. Romina Fiorotto1,
  9. Mario Strazzabosco1,3,‡,*

Article first published online: 27 AUG 2012

DOI: 10.1002/hep.25872

Issue

Hepatology

Hepatology

Volume 56, Issue 6, pages 2363–2374, December 2012

Additional Information

How to Cite

Spirli, C., Morell, C. M., Locatelli, L., Okolicsanyi, S., Ferrero, C., Kim, A. K., Fabris, L., Fiorotto, R. and Strazzabosco, M. (2012), Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib. Hepatology, 56: 2363–2374. doi: 10.1002/hep.25872

Author Information

  1. 1

    Liver Center & Section of Digestive Diseases, Department of Internal Medicine, Yale University, New Haven, CT

  2. 2

    Department of Surgical, Oncological, and Gastroenterological Sciences, University of Padova, Padova, Italy

  3. 3

    Department of Clinical Medicine and Prevention, University of Milan-Bicocca, Milan, Italy

  1. ‡

    fax: 203-785-7273

*M.D., Ph.D., Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, 333 Cedar Street, LMP 1080, New Haven, CT 06520

  1. †

    Potential conflict of interest: M. S. received research support from Onyx/Bayer for clinical studies with sorafenib on an unrelated project.

  2. ‡

    fax: 203-785-7273

Publication History

  1. Issue published online: 4 DEC 2012
  2. Article first published online: 27 AUG 2012
  3. Accepted manuscript online: 31 MAY 2012 01:08PM EST
  4. Manuscript Accepted: 25 MAY 2012
  5. Manuscript Received: 15 OCT 2011

Funded by

  • National Institutes of Health (NIH). Grant Numbers: DK079005, P30 DK34989
  • NIH to the Yale Liver Center. Grant Number: Telethon grant GGP09189
  • Liver Scholar Award (American Liver Foundation)

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View Full Article with Supporting Information (HTML) Get PDF (1256K)