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Steatohepatitis/Metabolic Liver Disease

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice†‡

  1. Jihong Lian1,2,§,
  2. Enhui Wei1,2,§,
  3. Shu Pei Wang3,
  4. Ariel D. Quiroga1,2,
  5. Lena Li1,2,
  6. Alba Di Pardo1,4,
  7. Jelske van der Veen1,5,
  8. Simonetta Sipione1,4,
  9. Grant A. Mitchell3,
  10. Richard Lehner1,2,6,¶,*

Article first published online: 4 DEC 2012

DOI: 10.1002/hep.25881

Issue

Hepatology

Hepatology

Volume 56, Issue 6, pages 2154–2162, December 2012

Additional Information

How to Cite

Lian, J., Wei, E., Wang, S. P., Quiroga, A. D., Li, L., Di Pardo, A., van der Veen, J., Sipione, S., Mitchell, G. A. and Lehner, R. (2012), Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice. Hepatology, 56: 2154–2162. doi: 10.1002/hep.25881

Author Information

  1. 1

    Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada

  2. 2

    Departments of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

  3. 3

    Division of Medical Genetics, Department of Pediatrics, Université de Montréal and CHU Sainte-Justine, Montreal, Quebec, Canada

  4. 4

    Departments of Pharmacology, University of Alberta, Edmonton, Alberta, Canada

  5. 5

    Departments of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  6. 6

    Departments of Cell Biology, University of Alberta, Edmonton, Alberta, Canada

  1. §

    These authors contributed equally to the work.

  2. fax: 780-492-3383

*Group on Molecular and Cell Biology of Lipids, University of Alberta, 328 Heritage Medical Research Centre, Edmonton, Alberta, Canada T6G 2S2 fax: 780-492-3383

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    The Lipid Analysis Core received financial support from the Women and Children Health Research Institute. A. D. P. was supported by a studentship from the Alberta Heritage Foundation for Medical Research. A. D. Q. was supported by a fellowship from the Heart and Stroke Foundation of Canada. S. S. and R.L. are a Scholar and a Scientist, respectively, of the Alberta Heritage Foundation for Medical Research. S. S. is a Canada Research Chair in Neurobiology of Huntington Disease. This work was supported by operating grants from the Canadian Institutes of Health Research (69043 to R. L., 111219 to S. S., and 221920 to G. A. M.) and the Canadian Diabetes Association (to J. v. d. V.) and a Pfizer CardioVascular Award (to R. L.).

  3. §

    These authors contributed equally to the work.

  4. fax: 780-492-3383

Publication History

  1. Issue published online: 4 DEC 2012
  2. Article first published online: 4 DEC 2012
  3. Accepted manuscript online: 18 JUN 2012 04:56AM EST
  4. Manuscript Accepted: 2 MAY 2012
  5. Manuscript Received: 8 NOV 2011

Funded by

  • Women and Children Health Research Institute
  • Alberta Heritage Foundation
  • Heart and Stroke Foundation of Canada
  • Alberta Heritage Foundation for Medical Research
  • Canada Research Chair in Neurobiology of Huntington Disease
  • Canadian Institutes of Health Research. Grant Numbers: 69043, 111219, 221920
  • Canadian Diabetes Association
  • Pfizer CardioVascular Award

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View Full Article with Supporting Information (HTML) Get PDF (1203K)