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Viral Hepatitis

High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials†‡

  1. Patrick Marcellin1,§,*,
  2. Hugo Cheinquer2,
  3. Manuela Curescu3,
  4. Geoffrey M. Dusheiko4,
  5. Peter Ferenci5,
  6. Andrzej Horban6,
  7. Donald Jensen7,
  8. Gabriella Lengyel8,
  9. Alessandra Mangia9,
  10. Denis Ouzan10,
  11. Massimo Puoti11,
  12. Maribel Rodriguez-Torres12,
  13. Mitchell L. Shiffman13,
  14. Manuela Schmitz14,
  15. Fernando Tatsch15,
  16. Mario Rizzetto16

Article first published online: 8 AUG 2012

DOI: 10.1002/hep.25892

Issue

Hepatology

Hepatology

Volume 56, Issue 6, pages 2039–2050, December 2012

Additional Information

How to Cite

Marcellin, P., Cheinquer, H., Curescu, M., Dusheiko, G. M., Ferenci, P., Horban, A., Jensen, D., Lengyel, G., Mangia, A., Ouzan, D., Puoti, M., Rodriguez-Torres, M., Shiffman, M. L., Schmitz, M., Tatsch, F. and Rizzetto, M. (2012), High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials. Hepatology, 56: 2039–2050. doi: 10.1002/hep.25892

Author Information

  1. 1

    Service d'Hépatologie, Hôpital Beaujon, APHP, University Paris-Diderot and INSERM CRB3, Clichy, France

  2. 2

    Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

  3. 3

    University of Medicine and Pharmacy Timisoara, Timisoara, Romania

  4. 4

    Royal Free and University College School of Medicine, London, United Kingdom

  5. 5

    Medical University of Vienna, Vienna, Austria

  6. 6

    Medical University Clinic of Infectious Diseases, Warsaw, Poland

  7. 7

    Center for Liver Diseases, Chicago, IL

  8. 8

    Semmelweis University, 2nd Dept. of Medicine, Budapest, Hungary

  9. 9

    Liver Unit, IRCCS Hospital ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Italy

  10. 10

    Institut Arnault Tzanck, Saint-Laurent-du-Var, France

  11. 11

    Department of Infectious Diseases AO Ospedale Niguarda Ca' Granda, Milano, Italy

  12. 12

    Fundación de Investigación, San Juan, PR

  13. 13

    Liver Institute of Virginia, Bon Secours Health System, Richmond, VA

  14. 14

    IST GmbH, Mannheim, Germany

  15. 15

    Roche, Basel, Switzerland

  16. 16

    University of Turin, Turin, Italy

  1. §

    fax: +33 (1) 47309440

*Service d'Hépatologie, Hôpital Beaujon, 100 Bvd du Général Leclerc, 92110 Clichy, France

  1. †

    Potential conflicts of interest: P.M., Consulting: Roche, Gilead, BMS, Vertex, Novartis, Pharmasset, Janssen, Tibotec, MSD, Abbott; Grant/Research Support: Roche, Gilead, BMS, Vertex, Novartis, Pharmasset, Janssen - Tibotec, MSD, Boehringer Ingelheim, Abbott Pfizer, Echosens; Speaking and Teaching: Roche, Gilead, BMS, Novartis, Pharmasset, Janssen, Tibotec, MSD; H.C., Advisory Committees or Review Panels: Janssen, Roche; Grant/Research Support: Bristol-Myers Squibb, Janssen, Roche; Speaking and Teaching: Janssen, Roche; P.F., Advisory Committees or Review Panels: Roche; Speaking and Teaching: Roche; Grant/Research Support: Roche; A.H., Advisory Committees or Review Panels: Gilead, Tibotec; D.J., Advisory Committees or Review Panels: Abbott, Boehringer Ingelheim, Bristol-Myers Squibb, Roche/Genentech, Merck, Pharmasset, Tibotec/J&J, Vertex, Pfizer; D.O., Consulting: Roche; M.P., Advisory Committees or Review Panels: Roche, MSD; M.R.T., Consulting: Hoffmann-La Roche, Abbott Labs, Anadys, Pharmasset, Akros, Bristol-Myers Squibb, Novartis, Merck, Inhibitex, Santaris, Glaxo Smithcline; Grant/Research Support: Vertex, Hoffmann-La Roche,GSK, Novartis, Bristol-Myers Squibb, Vertex Pharm, Idera, Conatus, Genentech, Mochida, Pharmasset, Sanofi-Aventis, Merck, Pfizer, Human Genome Sciences, Gilead, Johnson & Johnson, Zymogenetics, Akros, Scynexis, Santaris, Boehringer, Inhibitex, Idenix, Siemens, Anadys; M.L.S., Consulting: Conatus, Human Genome Sciences, Pfizer, Roche/Genentech. Romark, Merck,Exalenz; Speaking and Teaching: Bayer, BMS, Gilead, Roche/Genentech, Schering-Plough/Merck, Vertex,, Salix; Grant/Research Support: Abbott, Achillion, Anadys, BMS, Boehringer Ingelheim, Conatus, Gilead, Globeimmune, Human Genome Sciences, Idenix, Novartis, Roche/Genentech, Schering-Plough/Merck, Vertex, Zymogenetics, Mochida; Advisory Committees or Review Panels: Abbott, Achillion, Anadys, Bayer, BMS, Boehringer-Ingelheim, Conatus, Gilead, Globeimmune, Human Genome Sciences, Novartis, Pfizer, Roche/Genentech, Schering-Pough/Merck, Vertex, Zymogenetics; M.S. is an employee of IST GmBH. IST GmBH, have a contract with Roche to provide statistical support; F.T. is an employee of F. Hoffmann-La Roche and a shareholder of F. Hoffmann-La Roche; M.R., Advisory Committees or Review Panels: Roche, BMS, Merck, Janssen; M.C., G.M.D., G.L., A.M. have nothing to disclose.

  2. ‡

    Funded by Roche. Support for third-party writing assistance for this article was provided by F. Hoffmann-La Roche Ltd.

  3. §

    fax: +33 (1) 47309440

Publication History

  1. Issue published online: 4 DEC 2012
  2. Article first published online: 8 AUG 2012
  3. Accepted manuscript online: 18 JUN 2012 04:58AM EST
  4. Manuscript Accepted: 26 MAY 2012
  5. Manuscript Received: 13 FEB 2012

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