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Liver Biology/Pathobiology

The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species–generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice†‡§

  1. Ji Hoon Yu1,
  2. Bing-Mei Zhu2,
  3. Gregory Riedlinger3,
  4. Keunsoo Kang1,
  5. Lothar Hennighausen1,4,¶,*

Article first published online: 4 DEC 2012

DOI: 10.1002/hep.25900

Issue

Hepatology

Hepatology

Volume 56, Issue 6, pages 2375–2386, December 2012

Additional Information

How to Cite

Yu, J. H., Zhu, B.-M., Riedlinger, G., Kang, K. and Hennighausen, L. (2012), The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species–generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice. Hepatology, 56: 2375–2386. doi: 10.1002/hep.25900

Author Information

  1. 1

    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD

  2. 2

    Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, China

  3. 3

    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD

  4. 4

    Department of Nanobiomedical Science and WCU Research Center of Nanobiomedical Science, Dankook University, Cheonan, Chungnam, Republic of Korea

  1. fax: 301-480-7312

*Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Room 101, Bethesda, MD 20892-0822, fax: 301-480-7312

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    Supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases and in part by the World Class University Program, Ministry of Education, Science and Technology, through the National Research Foundation of Korea (grant R31-10069).

  3. §

    L. H. is an adjunct member of the Department of Nanobiomedical Science and WCU Research Center for Nanobiomedical Science.

  4. fax: 301-480-7312

Publication History

  1. Issue published online: 4 DEC 2012
  2. Article first published online: 4 DEC 2012
  3. Accepted manuscript online: 18 JUN 2012 11:57AM EST
  4. Manuscript Accepted: 1 JUN 2012
  5. Manuscript Received: 5 DEC 2011

Funded by

  • Intramural Research Program
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • World Class University Program, Ministry of Education, Science and Technology
  • National Research Foundation of Korea. Grant Number: R31-10069

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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_25900_sm_SuppFig1.tif1205KSupporting Information Figure 1.
HEP_25900_sm_SuppFig2.tif7327KSupporting Information Figure 2.
HEP_25900_sm_SuppFig3.tif2135KSupporting Information Figure 3.
HEP_25900_sm_SuppFig4.tif7308KSupporting Information Figure 4.
HEP_25900_sm_SuppFig5.tif142KSupporting Information Figure 5.
HEP_25900_sm_SuppFig6.tif1952KSupporting Information Figure 6.
HEP_25900_sm_SuppFig7.tif91KSupporting Information Figure 7.
HEP_25900_sm_SuppFig8.tif88KSupporting Information Figure 8.
HEP_25900_sm_SuppFig9.tif107KSupporting Information Figure 9.
HEP_25900_sm_SuppFig10.tif153KSupporting Information Figure 10.
HEP_25900_sm_SuppFig11.tif108KSupporting Information Figure 11.
HEP_25900_sm_SuppFig12.tif620KSupporting Information Figure 12.
HEP_25900_sm_SuppFig13.tif411KSupporting Information Figure 13.
HEP_25900_sm_SuppFig14.tif310KSupporting Information Figure 14.
HEP_25900_sm_SuppTab1.doc48KSupporting Information Table 1. A. Expression of Nox4, Bim and Socs2 genes in STAT5f/f and STAT5f/f;Alb-Cre liver tissue.
HEP_25900_sm_SuppTab2.doc42KSupporting Information Table 2. Expression of Nox4, Puma and Socs2 genes in Stat5+/+ and Stat5-/- MEFs.

Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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