Potential conflicts of interest: Alessio Aghemo, M.D.: Grant and research support: Roche, Gilead Sciences; Speaking and Teaching: Roche, Janssen; Travel support: BMS, Glaxo Smith-Kline, Bayer, Janssen, Roche. Massimo Colombo, M.D.: Grant and research support: Merck, Roche, BMS, Gilead Science; Advisory committees: Merck, Roche, Novartis, Bayer, BMS, Gilead Science, Tibotec, Vertex, Achillion; Speaking and teaching: Tibotec, Roche, Novartis, Bayer, BMS, Gilead Science, Vertex. Enrico Galmozzi, Ph.D., has nothing to disclose.