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Liver Failure/Cirrhosis/Portal Hypertension

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent†‡

  1. Tomonori Aoyama1,2,
  2. Yong-Han Paik3,
  3. Sumio Watanabe2,
  4. Benoît Laleu4,
  5. Francesca Gaggini4,
  6. Laetitia Fioraso-Cartier4,
  7. Sophie Molango4,
  8. Freddy Heitz4,
  9. Cédric Merlot4,
  10. Cédric Szyndralewiez4,
  11. Patrick Page4,
  12. David A. Brenner1,§,*

Article first published online: 4 DEC 2012

DOI: 10.1002/hep.25938

Issue

Hepatology

Hepatology

Volume 56, Issue 6, pages 2316–2327, December 2012

Additional Information

How to Cite

Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., Page, P. and Brenner, D. A. (2012), Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology, 56: 2316–2327. doi: 10.1002/hep.25938

Author Information

  1. 1

    Department of Medicine, University of California San Diego, La Jolla, CA

  2. 2

    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan

  3. 3

    Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

  4. 4

    GenKyoTex SA, Geneva, Switzerland

  1. §

    fax: 858-822-0084

*Department of Medicine, University of California San Diego, 1318A Biomedical Sciences Building, 9500 Gilman Drive, La Jolla, CA 92093-0602

  1. †

    Potential conflict of interest: B.L., F.G., L.F.-C., S.M., F.H., C.M., C.S., and P.P. are employees of GenKyoTex SA, which developed and provided the drug (GKT137831) used in this study.

  2. ‡

    This work was supported by the American Liver Foundation (grant nos.: 1 R24 DK090962, 5 P50 AA011999, and 5 R01 GM041804).

  3. §

    fax: 858-822-0084

Publication History

  1. Issue published online: 4 DEC 2012
  2. Article first published online: 4 DEC 2012
  3. Accepted manuscript online: 14 JUL 2012 03:10AM EST
  4. Manuscript Accepted: 13 JUN 2012
  5. Manuscript Received: 11 JAN 2012

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