SEARCH

SEARCH BY CITATION

Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_25938_sm_SuppFig1.TIF2555KSupplementary Fig.1 Enhanced liver fibrosis and inflammation after bile duct ligation in SOD1mu mice are suppressed by inhibition of NOX1/4 with GKT137831. Livers from WT or SOD1mu mice were analyzed at 21 days after bile duct ligation or sham operation (n=5). From the11th day after operation, mice were treated daily with NOX1/4 inhibitor or vehicle. (A) Fibrillar collagen deposition was evaluated by sirius red staining (original magnification /40), and (B) its quantification is shown. (C) The expression of α-SMA in the liver was detected by immunohistochemistry staining (original magnification /100). (D) Serum ALT levels were measured. (E) Hepatic expression of collagen a1(I) and TGF-β mRNA was measured by quantitative real-time PCR. NI: NOX1/4 inhibitor. *P<0.05
HEP_25938_sm_SuppInfo.doc67KSupporting Information

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.