Liver Failure/Cirrhosis/Portal Hypertension
Article first published online: 4 DEC 2012
Copyright © 2012 American Association for the Study of Liver Diseases
Volume 56, Issue 6, pages 2316–2327, December 2012
How to Cite
Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., Page, P. and Brenner, D. A. (2012), Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology, 56: 2316–2327. doi: 10.1002/hep.25938
Potential conflict of interest: B.L., F.G., L.F.-C., S.M., F.H., C.M., C.S., and P.P. are employees of GenKyoTex SA, which developed and provided the drug (GKT137831) used in this study.
This work was supported by the American Liver Foundation (grant nos.: 1 R24 DK090962, 5 P50 AA011999, and 5 R01 GM041804).
- Issue published online: 4 DEC 2012
- Article first published online: 4 DEC 2012
- Accepted manuscript online: 14 JUL 2012 03:10AM EST
- Manuscript Accepted: 13 JUN 2012
- Manuscript Received: 11 JAN 2012
Additional Supporting Information may be found in the online version of this article.
|HEP_25938_sm_SuppFig1.TIF||2555K||Supplementary Fig.1 Enhanced liver fibrosis and inflammation after bile duct ligation in SOD1mu mice are suppressed by inhibition of NOX1/4 with GKT137831. Livers from WT or SOD1mu mice were analyzed at 21 days after bile duct ligation or sham operation (n=5). From the11th day after operation, mice were treated daily with NOX1/4 inhibitor or vehicle. (A) Fibrillar collagen deposition was evaluated by sirius red staining (original magnification /40), and (B) its quantification is shown. (C) The expression of α-SMA in the liver was detected by immunohistochemistry staining (original magnification /100). (D) Serum ALT levels were measured. (E) Hepatic expression of collagen a1(I) and TGF-β mRNA was measured by quantitative real-time PCR. NI: NOX1/4 inhibitor. *P<0.05|
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