fax: 314-577-8125. Copyright © 2012 by the American Association for the Study of Liver Diseases. View this article online at wileyonlinelibrary.com. DOI 10.1002/hep.25953 Potential conflict of interest: Nothing to report
Editorial
Excess cholesterol and fat in the diet: A dangerous liaison for energy expenditure and the liver†
Article first published online: 7 JAN 2013
DOI: 10.1002/hep.25953
Copyright © 2012 American Association for the Study of Liver Diseases
Additional Information
How to Cite
Neuschwander-Tetri, B. A. and Wang, D. Q.-H. (2013), Excess cholesterol and fat in the diet: A dangerous liaison for energy expenditure and the liver. Hepatology, 57: 7–9. doi: 10.1002/hep.25953
- †
Potential conflict of interest: Nothing to report.
- ‡
fax: 314-577-8125. Copyright © 2012 by the American Association for the Study of Liver Diseases. View this article online at wileyonlinelibrary.com. DOI 10.1002/hep.25953 Potential conflict of interest: Nothing to report
Publication History
- Issue published online: 7 JAN 2013
- Article first published online: 7 JAN 2013
- Accepted manuscript online: 14 JUL 2012 03:11AM EST
- Manuscript Accepted: 25 JUN 2012
- Manuscript Revised: 22 JUN 2012
- Manuscript Received: 1 JUN 2012
References
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- 2, , , , , , et al. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. HEPATOLOGY 2013; 58: 81–91.
- 3, . LXRs and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 2006; 68: 159-191.
- 4, , , , , , et al. Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis. Am J Physiol Endocrinol Metab 2009; 297: E462-473.
- 5, , , , , , et al. LXRs regulate the balance between fat storage and oxidation. Cell Metab 2005; 1: 231-244.
- 6. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. HEPATOLOGY 2010; 52: 774-788.
- 7, , , , . Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic fatty liver disease. J Lipids 2012; 2012: 302847.
- 8, , , , , , et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006; 439: 484-489.
- 9, , , , . The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol 2011; 54: 1263-1272.
- 10, , , , , , et al. Role of LXRs in control of lipogenesis. Genes Dev 2000; 14: 2831-2838.

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