TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis†
Article first published online: 11 FEB 2013
Copyright © 2012 American Association for the Study of Liver Diseases
Volume 57, Issue 4, pages 1416–1425, April 2013
How to Cite
Matsubara, T., Kanto, T., Kuroda, S., Yoshio, S., Higashitani, K., Kakita, N., Miyazaki, M., Sakakibara, M., Hiramatsu, N., Kasahara, A., Tomimaru, Y., Tomokuni, A., Nagano, H., Hayashi, N. and Takehara, T. (2013), TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis. Hepatology, 57: 1416–1425. doi: 10.1002/hep.25965
Potential conflict of interest: Nothing to report.
- Issue published online: 8 APR 2013
- Article first published online: 11 FEB 2013
- Accepted manuscript online: 19 JUL 2012 05:45AM EST
- Manuscript Accepted: 13 JUN 2012
- Manuscript Received: 16 FEB 2012
- Grant-In-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Grant-In-Aid from the Ministry of Health, Labor, and Welfare of Japan
Additional Supporting Information may be found in the online version of this article.
|HEP_25965_sm_SuppFig1.tif||77K||Supporting Information Figure 1. Frequency of TEMs is comparable in HCC patients regardless of etiology. The frequencies of peripheral TEMs are shown for HCC patients with or without HCV infection (n=89 and n=26, respectively). The group without HCV infection included patients with HBV infection or those without HBV nor HCV (HBV-HCC and Non-B, Non-C [NBNC] HCC patients). n.s., not significant by Mann-Whitney non-parametric U test.|
|HEP_25965_sm_SuppFig2.tif||63K||Supporting Information Figure 2. Peripheral frequency of TEMs is not related to the overall survival in patients with HCC. In patients with HCC who underwent RFA or the operation, the overall survival rate after the treatment was compared between those with TEMhigh (frequency of TEMs ≥ 2.75; n=45) and TEMlow (frequency of TEMs < 2.75; n=44) using the Kaplan-Meier method, with the log-rank test for comparison. TEMhigh and TEMlow, see Table 2. P=0.36|
|HEP_25965_sm_SuppFig3.tif||124K||Supporting Information Figure 3. Correlation between the frequency of TEMs and serum levels of angiogenesis factors All plots indicate the correlation between TEM frequency and VEGF, ANG-2, sVEGFR-1 or MIF. The numbers of patients examined were 32, 37, 23 and 31, respectively. Analyses were based on Pearson's correlation coefficient.|
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