Additional Supporting Information may be found in the online version of this article.

HEP_25965_sm_SuppFig1.tif77KSupporting Information Figure 1. Frequency of TEMs is comparable in HCC patients regardless of etiology. The frequencies of peripheral TEMs are shown for HCC patients with or without HCV infection (n=89 and n=26, respectively). The group without HCV infection included patients with HBV infection or those without HBV nor HCV (HBV-HCC and Non-B, Non-C [NBNC] HCC patients). n.s., not significant by Mann-Whitney non-parametric U test.
HEP_25965_sm_SuppFig2.tif63KSupporting Information Figure 2. Peripheral frequency of TEMs is not related to the overall survival in patients with HCC. In patients with HCC who underwent RFA or the operation, the overall survival rate after the treatment was compared between those with TEMhigh (frequency of TEMs ≥ 2.75; n=45) and TEMlow (frequency of TEMs < 2.75; n=44) using the Kaplan-Meier method, with the log-rank test for comparison. TEMhigh and TEMlow, see Table 2. P=0.36
HEP_25965_sm_SuppFig3.tif124KSupporting Information Figure 3. Correlation between the frequency of TEMs and serum levels of angiogenesis factors All plots indicate the correlation between TEM frequency and VEGF, ANG-2, sVEGFR-1 or MIF. The numbers of patients examined were 32, 37, 23 and 31, respectively. Analyses were based on Pearson's correlation coefficient.

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