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Steatohepatitis/Metabolic Liver Disease

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice†‡

  1. Kouichi Miura1,2,*,
  2. Ling Yang1,
  3. Nico van Rooijen3,
  4. David A. Brenner1,
  5. Hirohide Ohnishi2,
  6. Ekihiro Seki1,*

Article first published online: 5 FEB 2013

DOI: 10.1002/hep.26081

Issue

Hepatology

Hepatology

Volume 57, Issue 2, pages 577–589, February 2013

Additional Information

How to Cite

Miura, K., Yang, L., van Rooijen, N., Brenner, D. A., Ohnishi, H. and Seki, E. (2013), Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology, 57: 577–589. doi: 10.1002/hep.26081

Author Information

  1. 1

    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA

  2. 2

    Department of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan

  3. 3

    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Amsterdam, Netherlands

*Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita-shi, Akita, Japan 010-8543.

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    This study was supported by National Institutes of Health Grants R01AA02172 (to E. S.), R01DK085252 (to E. S.), R24DK090962 (to D. A. B.), and R01GM041804 (to D. A. B.); a pilot grant from the University of California, San Diego Digestive Diseases Research Development Center (DK080506) (to E. S.); the Takeda Science Foundation (K. M.); The Mochida Memorial Foundation for Medical and Pharmaceutical Research (K. M.); the Mishima Kaiun Memorial Foundation (K. M.); and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (to K. M.).

Publication History

  1. Issue published online: 5 FEB 2013
  2. Article first published online: 5 FEB 2013
  3. Accepted manuscript online: 17 SEP 2012 02:47AM EST
  4. Manuscript Accepted: 2 SEP 2012
  5. Manuscript Received: 6 APR 2012

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View Full Article with Supporting Information (HTML) Get PDF (1304K)