Steatohepatitis/Metabolic Liver Disease
Article first published online: 8 JAN 2013
Copyright © 2012 American Association for the Study of Liver Diseases
Volume 57, Issue 2, pages 601–609, February 2013
How to Cite
Zhu, L., Baker, S. S., Gill, C., Liu, W., Alkhouri, R., Baker, R. D. and Gill, S. R. (2013), Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH. Hepatology, 57: 601–609. doi: 10.1002/hep.26093
Potential conflict of interest: Nothing to report.
This work was supported by a grant from the Peter and Tommy Fund, Inc. (Buffalo, NY; to S.S.B.), a grant from the SKI4E Fund (to S.S.B.), and a departmental start-up fund (to L.Z.).
- Issue published online: 5 FEB 2013
- Article first published online: 8 JAN 2013
- Accepted manuscript online: 11 OCT 2012 01:30AM EST
- Manuscript Accepted: 24 SEP 2012
- Manuscript Received: 12 AUG 2012
Additional Supporting Information may be found in the online version of this article.
|HEP_26093_sm_SuppTab1.doc||34K||Supporting Information Table 1.|
|HEP_26093_sm_SuppTab2.doc||28K||Supporting Information Table 2.|
|HEP_26093_sm_SuppTab3.doc||38K||Supporting Information Table 3.|
|HEP_26093_sm_SuppTab4.doc||42K||Supporting Information Table 4.|
|HEP_26093_sm_SuppFig1.tif||178K||Supplementary Figure 1, Reduced species richness but not phylogenetic diversity in the gut microbiome of the obese and the NASH patients. Alpha diversities (phylogenetic distance and species richness) were evaluated based on the rarefied OTU tables. The sampling sizes were 10, 1268, 2526, 3784, and 5042 OTUs. (A) Phylogenetic diversity metric based on PD_whole_tree method. No significant difference was observed. (B) Species richness metric based on Chao1 method. Significant differences were observed at 1268, 2526, 3784, and 5042 OTUs (P<0.05, ANOVA). Tukey's tests indicated significant difference between the normal and the obese groups.|
|HEP_26093_sm_SuppFig2.tif||3604K||Supplementary Figure 2, UniFrac based principle coordinates analysis. The gut microbiomes did not cluster by age, ethnicity or gender, but clustered by health status with exceptions.|
|HEP_26093_sm_SuppFig3.tif||1567K||Supplementary Figure 3, Phylum distribution of the individual microbiomes of the normal subjects, the obese patients and the NASH patients.|
|HEP_26093_sm_SuppFig4.tif||4285K||Supplementary Figure 4, Alignment of the OTU #20341 sequence to the 16s rRNA sequences of the Escherichia species and Cronobacter dubinensis.|
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