SEARCH

SEARCH BY CITATION

Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
HEP_26122_sm_SuppFig1ab.tif12949KSupporting Information Figure 1ab. Immunohistochemical expression of CK19, EpCAM and c-KIT was analyzed using 15 tissue samples of each MFI pattern including 2 cases with histologically cholangiocellular differentiation. In the reticular type HCCs, (a) expression of CK19 and EpCAM was detected in 1 case with cholangiocellular differentiation. (b) The other 14 cases of the reticular type did not express the progenitor cell markers. In the thunderbolt type HCCs, (c) both CK19 and EpCAM expressed in 1 case with cholangiocellular differentiation. (d) EpCAM expression was not detected in 11 cases of the thunderbolt type, (e) but the other 3 cases expressed EpCAM protein. Expression of c-KIT was not clearly identified in all of the samples examined. (f) There was no significant relationship between the progenitor cell markers and the thunderbolt appearance, as well as geminin expression.
HEP_26122_sm_SuppFig1cd.tif13375KSupporting Information Figure 1cd. Immunohistochemical expression of CK19, EpCAM and c-KIT was analyzed using 15 tissue samples of each MFI pattern including 2 cases with histologically cholangiocellular differentiation. In the reticular type HCCs, (a) expression of CK19 and EpCAM was detected in 1 case with cholangiocellular differentiation. (b) The other 14 cases of the reticular type did not express the progenitor cell markers. In the thunderbolt type HCCs, (c) both CK19 and EpCAM expressed in 1 case with cholangiocellular differentiation. (d) EpCAM expression was not detected in 11 cases of the thunderbolt type, (e) but the other 3 cases expressed EpCAM protein. Expression of c-KIT was not clearly identified in all of the samples examined. (f) There was no significant relationship between the progenitor cell markers and the thunderbolt appearance, as well as geminin expression.
HEP_26122_sm_SuppFig1ef.tif7060KSupporting Information Figure 1ef. Immunohistochemical expression of CK19, EpCAM and c-KIT was analyzed using 15 tissue samples of each MFI pattern including 2 cases with histologically cholangiocellular differentiation. In the reticular type HCCs, (a) expression of CK19 and EpCAM was detected in 1 case with cholangiocellular differentiation. (b) The other 14 cases of the reticular type did not express the progenitor cell markers. In the thunderbolt type HCCs, (c) both CK19 and EpCAM expressed in 1 case with cholangiocellular differentiation. (d) EpCAM expression was not detected in 11 cases of the thunderbolt type, (e) but the other 3 cases expressed EpCAM protein. Expression of c-KIT was not clearly identified in all of the samples examined. (f) There was no significant relationship between the progenitor cell markers and the thunderbolt appearance, as well as geminin expression.
HEP_26122_sm_SuppFig2.tif7115KSupporting Information Figure 2. Immunohistochemical analysis of Ki67 in HCC cancer tissues expressing the geminin protein at low levels (a) or at high levels (b). The frequency of Ki67-positive cancer cells was revealed to correlate significantly to geminin expression (P=0.0112).
HEP_26122_sm_SuppTables.doc77KSupporting Information Tables.

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.