Potential conflict of interest: Nothing to report.
Liver Failure/Cirrhosis/Portal Hypertension
Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction†
Version of Record online: 25 JAN 2013
Copyright © 2012 American Association for the Study of Liver Diseases
Volume 57, Issue 3, pages 1172–1181, March 2013
How to Cite
La Mura, V., Pasarín, M., Meireles, C. Z., Miquel, R., Rodríguez-Vilarrupla, A., Hide, D., Gracia-Sancho, J., García-Pagán, J. C., Bosch, J. and Abraldes, J. G. (2013), Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction. Hepatology, 57: 1172–1181. doi: 10.1002/hep.26127
- Issue online: 28 FEB 2013
- Version of Record online: 25 JAN 2013
- Accepted manuscript online: 26 NOV 2012 12:00AM EST
- Manuscript Accepted: 15 OCT 2012
- Manuscript Received: 30 MAY 2012
- Instituto de Salud Carlos III. Grant Number: FIS PI11/00883
- FEDER funds (EU, “Una manera de hacer Europa”)
- Esther Koplowitz Centre, Barcelona
Additional Supporting Information may be found in the online version of this article.
|HEP_26127_sm_SuppFig1.tif||4539K||Supporting Information Figure 1. Portal perfusion pressure (A) and vasodilatory response to acetylcholine (B) 6 hours after LPS/saline exposure.|
|HEP_26127_sm_SuppFig2.tif||8053K||Supporting Information Figure 2. LPS administration did not upregulate liver alpha smooth muscle actin (α-SMA) (A) or RhoA/Rho kinase (ROCKII) pathway (B,C) (n=4 for each condition).|
|HEP_26127_sm_SuppFig3.tif||7420K||Supporting Information Figure 3. LPS upregulated liver IL-6 (A) and iNOS expression (B) at 24 hours. Simvastatin attenuated the increase in IL-6, but not the increase in iNOS. LPS induced an early increase of TNF-alpha that was not attenuated by treatment with simvastatin (C) (*p<0.05 in comparison with groups treated with saline). Liver arginase was slightly decreased (non-significantly) by LPS in the three groups of rats (D).|
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