Additional Supporting Information may be found in the online version of this article.

HEP_26127_sm_SuppFig1.tif4539KSupporting Information Figure 1. Portal perfusion pressure (A) and vasodilatory response to acetylcholine (B) 6 hours after LPS/saline exposure.
HEP_26127_sm_SuppFig2.tif8053KSupporting Information Figure 2. LPS administration did not upregulate liver alpha smooth muscle actin (α-SMA) (A) or RhoA/Rho kinase (ROCKII) pathway (B,C) (n=4 for each condition).
HEP_26127_sm_SuppFig3.tif7420KSupporting Information Figure 3. LPS upregulated liver IL-6 (A) and iNOS expression (B) at 24 hours. Simvastatin attenuated the increase in IL-6, but not the increase in iNOS. LPS induced an early increase of TNF-alpha that was not attenuated by treatment with simvastatin (C) (*p<0.05 in comparison with groups treated with saline). Liver arginase was slightly decreased (non-significantly) by LPS in the three groups of rats (D).

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