Viral Hepatitis

Chimeric hepatitis B virus/hepatitis C virus envelope proteins elicit broadly neutralizing antibodies and constitute a potential bivalent prophylactic vaccine†‡

  1. Elodie Beaumont1,
  2. Romuald Patient1,
  3. Christophe Hourioux1,
  4. Isabelle Dimier-Poisson2,
  5. Philippe Roingeard1,§,*

Article first published online: 14 MAR 2013

DOI: 10.1002/hep.26132

Issue

Hepatology

Hepatology

Volume 57, Issue 4, pages 1303–1313, April 2013

Additional Information

How to Cite

Beaumont, E., Patient, R., Hourioux, C., Dimier-Poisson, I. and Roingeard, P. (2013), Chimeric hepatitis B virus/hepatitis C virus envelope proteins elicit broadly neutralizing antibodies and constitute a potential bivalent prophylactic vaccine. Hepatology, 57: 1303–1313. doi: 10.1002/hep.26132

Author Information

  1. 1

    INSERM U966, Université François Rabelais and CHRU de Tours, Tours, France

  2. 2

    UMR INRA 1282, Université François Rabelais, Tours, France

  1. §

    fax: (33) 2 47 47 82 07.

*Pharm.D., Ph.D., INSERM U966, Laboratoire de Biologie Cellulaire, Faculté de Médecine de Tours, 10 Boulevard Tonnellé, F-37032 Tours, France

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    This study was supported by the Institut Mérieux, the “Hepatibivax” grant from the “Emergence” program of the Agence Nationale pour la Recherche (France), and the FEDER (Fonds Européens de Développements en Region–Région Centre, France) program. The authors thank Dr. Takaji Wakita for the JFH-1 virus strain, Dr. Jens Bukh for the chimeric JFH-1 genomes, S52/JFH1, H77/JFH1, and J4/JFH1, Dr. Charles Rice for the Huh7.5 cell line, Dr. Jonathan Ball for the UKN5.23, UKN 2a1.2, and UKN3A.1.28 plasmids, Dr. Jean Dubuisson for the 7a plasmid and the mAb H52, Dr Harry Greenberg for the mAb A4, Dr. Camille Sureau for the polyclonal anti-HBs Ab, R247, and Dr. Mansun Law for the mAbs, AR3A and AR5A.

  3. §

    fax: (33) 2 47 47 82 07.

Publication History

  1. Issue published online: 8 APR 2013
  2. Article first published online: 14 MAR 2013
  3. Accepted manuscript online: 13 NOV 2012 11:01PM EST
  4. Manuscript Revised: 17 OCT 2012
  5. Manuscript Accepted: 17 OCT 2012
  6. Manuscript Received: 31 MAY 2012

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