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Steatohepatitis/Metabolic Liver Disease

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats†

  1. Naoki Kumashiro1,2,
  2. Toru Yoshimura2,
  3. Jennifer L. Cantley1,2,
  4. Sachin K. Majumdar2,
  5. Fitsum Guebre-Egziabher2,
  6. Romy Kursawe3,
  7. Daniel F. Vatner2,
  8. Ioana Fat2,
  9. Mario Kahn2,
  10. Derek M. Erion1,2,4,
  11. Xian-Man Zhang1,2,
  12. Dongyan Zhang1,2,4,
  13. Vara Prasad Manchem5,
  14. Sanjay Bhanot5,
  15. Glenn S. Gerhard6,
  16. Kitt F. Petersen2,
  17. Gary W. Cline2,
  18. Varman T. Samuel2,7,
  19. Gerald I. Shulman1,2,4,‡,*

Article first published online: 25 JAN 2013

DOI: 10.1002/hep.26170

Issue

Hepatology

Hepatology

Volume 57, Issue 5, pages 1763–1772, May 2013

Additional Information

How to Cite

Kumashiro, N., Yoshimura, T., Cantley, J. L., Majumdar, S. K., Guebre-Egziabher, F., Kursawe, R., Vatner, D. F., Fat, I., Kahn, M., Erion, D. M., Zhang, X.-M., Zhang, D., Manchem, V. P., Bhanot, S., Gerhard, G. S., Petersen, K. F., Cline, G. W., Samuel, V. T. and Shulman, G. I. (2013), Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology, 57: 1763–1772. doi: 10.1002/hep.26170

Author Information

  1. 1

    Howard Hughes Medical Institute, Yale University, School of Medicine, New Haven, CT

  2. 2

    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT

  3. 3

    Department of Pediatrics, Yale University School of Medicine, New Haven, CT

  4. 4

    Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT

  5. 5

    ISIS Pharmaceuticals, Carlsbad, CA

  6. 6

    Weis Center for Research, Geisinger Clinic, Danville, PA

  7. 7

    Veterans Affairs Medical Center, West Haven CT

  1. ‡

    fax: 203-737-4059

*Howard Hughes Medical Institute, Yale University, Department of Internal Medicine, Yale University School of Medicine, P.O. Box 9812, New Haven, CT, 06536-8012

  1. †

    Potential conflict of interest: Nothing to report.

  2. ‡

    fax: 203-737-4059

Publication History

  1. Issue published online: 22 APR 2013
  2. Article first published online: 25 JAN 2013
  3. Accepted manuscript online: 23 NOV 2012 04:35AM EST
  4. Manuscript Accepted: 7 NOV 2012
  5. Manuscript Received: 5 SEP 2012

Funded by

  • National Institutes of Health. Grant Numbers: DK-085638, DK-40936, AG-23686, RR-024139, P30 DK-34989, P30 DK-45735
  • VA Merit Grant
  • Manpei Suzuki Diabetes Foundation fellowship
  • Distinguished Clinical Scientist Award from the American Diabetes Association

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View Full Article with Supporting Information (HTML) Get PDF (779K)