Potential conflict of interest: Nothing to report.
Steatohepatitis and Metabolic Liver Disease
Desmosterol in human nonalcoholic steatohepatitis
Version of Record online: 29 JUL 2013
Copyright © 2013 American Association for the Study of Liver Diseases
Volume 58, Issue 3, pages 976–982, September 2013
How to Cite
Simonen, M., Männistö, V., Leppänen, J., Kaminska, D., Kärjä, V., Venesmaa, S., Käkelä, P., Kuusisto, J., Gylling, H., Laakso, M. and Pihlajamäki, J. (2013), Desmosterol in human nonalcoholic steatohepatitis. Hepatology, 58: 976–982. doi: 10.1002/hep.26342
Supported by a grant from the Academy of Finland (to J.P., Contract no. 120979; 138006; to M.L., Contract no. 124243), the Finnish Diabetes Research Foundation (to J.P. and M.L.), the Finnish Cultural Foundation (to J.P.), the Finnish Heart Foundation (to M.L.), TEKES (to M.L., Contract no. 1510/31/06), and Commission of the European Community (to M.L., Contract no. LSHM-CT-2004-512013 EUGENE2).
- Issue online: 29 AUG 2013
- Version of Record online: 29 JUL 2013
- Accepted manuscript online: 27 FEB 2013 09:13AM EST
- Manuscript Accepted: 14 FEB 2013
- Manuscript Received: 5 DEC 2012
Additional Supporting Information may be found in the online version of this article.
|hep26342-sup-0001-suppfig1.tif||468K||Supporting Information Figure 1|
|hep26342-sup-0002-supptab1.doc||36K||Supporting Table 1. Clinical characteristics (mean ± SD) of obese individuals according to liver phenotype with those study subjects without distinct phenotype.|
|hep26342-sup-0003-supptab2.doc||62K||Supporting Table 2. Liver histology in study subjects by NASH Clinical Research Network Scoring System Definitions and Scores (27).|
|hep26342-sup-0004-supptab3.doc||27K||Supporting Table 3. Clinical characteristics (mean ± SD) of obese individuals divided by the use of statins.|
|hep26342-sup-0005-supptab4.doc||22K||Supporting Table 4. Characteristics of all study subjects and subjects with available samples for liver sterol measurement and liver gene expression analysis (mean ± SD). There was no statistically significant difference between the groups.|
|hep26342-sup-0006-supptab5.doc||21K||Supporting Table 5. Spearman's correlations of serum total cholesterol, desmosterol, cholestenol and lathosterol with mRNA expression of SREBP1a and SREBP1c in liver tissue (n=80).|
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