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Additional Supporting Information may be found in the online version of this article.

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Supporting Table 1. Univariate analysis on risk-factors for HBV S-gene mutations at inclusion and during follow-up (L-nucleoside-associated pol-gene/antiviral-associated S-gene)

Supporting Table 2. Full description of HBV mutations at inclusion and during follow-up

Supporting Table 3. Clinical and virological description of patients with liver biopsies

Supporting Figure 1. Handling missing HBV mutation data

Supporting Figure 2. Clinical description of liver enzymes and HBV-DNA viral load during follow-up among several patients with incident S-gene mutations

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