Potential conflicts of interest: Nothing to report.
Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice
Article first published online: 1 JUL 2013
Copyright © 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 2, pages 788–798, August 2013
How to Cite
Wang, C.-Y. and Knutson, M. D. (2013), Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice. Hepatology, 58: 788–798. doi: 10.1002/hep.26401
This work was supported by the National Institutes of Health (grant no.: R01 DK080706; to M.D.K.) and the International Life Sciences Institute North America Future Leader Award (to M.D.K.). The authors graciously thank the late Dr. Hiromi Gunshin and Dr. Nancy Andrews (Duke University School of Medicine, Durham, NC) for providing the mutant mice used in these studies, and Dr. Philippe Gros (Mcgill University, Montreal, Canada) for the auto-OMT1 antiserum.
- Issue published online: 29 JUL 2013
- Article first published online: 1 JUL 2013
- Accepted manuscript online: 19 MAR 2013 12:43AM EST
- Manuscript Accepted: 14 MAR 2013
- Manuscript Received: 13 SEP 2012
Additional Supporting Information may be found in the online version of this article.
|hep26401-sup-0001-suppfig1.tif||3224K||Figure S1. Localization of DMT1 in liver. (A) DMT1 immunofluorescence (Alexa Fluor 488, green) and 4',6-diamino-2-phenylindole (DAPI)-stained nuclei (blue) in human liver section. DMT1 was detected by using a rabbit anti-human DMT1 antibody (Prestige Antibodies, HPA032140, Sigma-Aldrich) that was raised against an epitope shared by all known DMT1 isoforms. (B) Human liver section incubated with secondary antibody alone as a negative control. Images were obtained by using an Olympus IX81-DSU spinning disk confocal fluorescent microscope, original magnification × 20.|
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