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Additional Supporting Information may be found in the online version of this article.

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hep26413-sup-0001-suppfig1.pptx748K

Supplemental Figure 1. qRT-PCR validation of the microarray results

Gene expression of selected targets in Sirt6-/- hepatocytes from microarray data in comparison to qRT-PCR. Data are referenced to corresponding Sirt6+/+ hepatocytes. (A) shows the upregulated and (B) downregulated genes based on the microarray analyses results. (C) Corresponding correlation plot indicating a high concordance between both methods. (Pearson correlation r=0.85; P-value =<0.001)

hep26413-sup-0002-suppfig2.pptx203K

Supplemental Figure 2. Functional networks by Ingenuity Pathway Analysis Software

Functional networks associated with SIRT6 signature were determined using Ingenuity Pathway Analyses Software.

hep26413-sup-0003-suppfig3.pptx73K

Supplemental Figure 3. SIRT6 signature in other cancers

(A) SIRT6 signature and clinical outcome of cancer patients from different types of cancer; integrative meta-analysis of genomic data from 40 primary tumors using the Oncomine Microarray database. Data are presented as the mean odds ratio ± SD with P < 0.0001. (B) Number of studies with overexpression of SIRT6 signature. The table shows No. of studies in reference to corresponding clinic-pathological features, Threshold (odds ratio): 2.0, Threshold (p-Value): <0.0001.

hep26413-sup-0004-supptab1.doc1233KSupplemental Table 1. Sirt6 gene expression signature.
hep26413-sup-0005-supptab2.doc180KSupplemental Table 2. Patients at risk.
hep26413-sup-0006-supptab3.doc45KSupplemental Table 3. Top Gene Sets enriched for SIRT6 signalling was identified by the GSEA Microarray tool.
hep26413-sup-0007-supptab4.doc31KSupplemental Table 4. Primer sequences.
hep26413-sup-0008-suppinfo.doc29KSupporting Information

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