Potential conflict of interest: Nothing to report.
Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection
Article first published online: 29 JUL 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 3, pages 881–889, September 2013
How to Cite
Ashraf, S., Nitschke, K., Warshow, U. M., Brooks, C. R., Kim, A. Y., Lauer, G. M., Hydes, T. J., Cramp, M. E., Alexander, G., Little, A.-M., Thimme, R., Neumann-Haefelin, C. and Khakoo, S. I. (2013), Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection. Hepatology, 58: 881–889. doi: 10.1002/hep.26415
Supported by grants from the Wellcome Trust (to S.I.K.), the Deutsche Forschungsgemeinschaft DFG (TH-719/3-1 to R.T. and NE1567/1-1 to C.N.H.) and the National Institutes of Health, grants U19 AI0663445 (to G.M.L. and A.Y.K.), R01 DA033541 (to A.Y.K.), and U19 AI082630 (to G.M.L.).
- Issue published online: 29 AUG 2013
- Article first published online: 29 JUL 2013
- Accepted manuscript online: 26 MAR 2013 12:18PM EST
- Manuscript Accepted: 21 MAR 2013
- Manuscript Received: 30 AUG 2012
Additional Supporting Information may be found in the online version of this article.
Supporting Tables 1A and 1B: Association of specific HLA-B alleles with Tapasin G (A) and Tapasin C alleles (B). Alleles with aspartate at residue 114 are shown in bold type. P values were determined using Fisher's exact test.
Supporting Table 2: A comparison of HLA allelelic frequencies between the UK (n = 420) and US (n = 249) cohorts. The difference in overall allelic frequencies between the two populations was calculated using the Chi-square test, and the p values are shown in parentheses.
Supporting Table 3: The association of tapasin genotype with outcome of HCV infection in the USA cohort stratified by possession of protective KIR ligands ie 2 group 1 HLA-C alleles (HLA-C1C1). In all table the numbers in each group are shown with the percentages in brackets. For the Tapasin genotype the denominator is “n” and for the HLA-B114D analysis the denominator is “2n”. P values were determined using Fisher's exact test.
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