These authors contributed equally to this work.
Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients
Article first published online: 19 SEP 2013
© 2013 by the American Association for the Study of Liver Diseases
Volume 58, Issue 5, pages 1824–1835, November 2013
How to Cite
Benítez, C., Londoño, M.-C., Miquel, R., Manzia, T.-M., Abraldes, J. G., Lozano, J.-J., Martínez-Llordella, M., López, M., Angelico, R., Bohne, F., Sese, P., Daoud, F., Larcier, P., Roelen, D. L., Claas, F., Whitehouse, G., Lerut, J., Pirenne, J., Rimola, A., Tisone, G. and Sánchez-Fueyo, A. (2013), Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients. Hepatology, 58: 1824–1835. doi: 10.1002/hep.26426
Potential conflict of interest: Dr. Larcier was employed by TcLand Expression S.A. Dr. Lerut received grants from Fresenius Biotech. Dr. Daoud consults for Medextens.
The study was conducted as part of the European Commission supported RISET consortium (Reprogramming the Immune System for the Establishment of Tolerance). Furthermore, the work was funded by TcLand Expression S.A. and by a grant from the Ministry of Education & Science, Spain (SAF2008-04092) to A.S-F. C.B. was supported by Fundación BBVA and by the Catalan Society of Transplantation. F.B. was supported by a research fellowship of the Deutsche Forschungsgemeinschaft (DfG reference BO 3370/1-1). CIBEREHD is funded by the Instituto de Salud Carlos III Spain.
See Editorial on Page 1529
- Issue published online: 30 OCT 2013
- Article first published online: 19 SEP 2013
- Accepted manuscript online: 26 MAR 2013 12:21PM EST
- Manuscript Accepted: 22 MAR 2013
- Manuscript Received: 12 JUL 2012
Lifelong immunosuppression increases morbidity and mortality in liver transplantation. Discontinuation of immunosuppressive drugs could lessen this burden, but the safety, applicability, and clinical outcomes of this strategy need to be carefully defined. We enrolled 102 stable liver recipients at least 3 years after transplantation in a single-arm multicenter immunosuppression withdrawal trial. Drugs were gradually discontinued over a 6 to 9-month period. The primary endpoint was the development of operational tolerance, defined as successful immunosuppressive drug cessation maintained for at least 12 months with stable graft function and no histopathologic evidence of rejection. Out of the 98 recipients evaluated, 57 rejected and 41 successfully discontinued all immunosuppressive drugs. In nontolerant recipients rejection episodes were mild and resolved over 5.6 months (two nontolerant patients still exhibited mild gradually improving cholestasis at the end of follow-up). In tolerant recipients no progressive clinically significant histological damage was apparent in follow-up protocol biopsies performed up to 3 years following drug withdrawal. Tolerance was independently associated with time since transplantation (odds ratio [OR] 1.353; P = 0.0001), recipient age (OR 1.073; P = 0.009), and male gender (OR 4.657; P = 0.016). A predictive model incorporating the first two clinical variables identified subgroups of recipients with very high (79%), intermediate (30%-38%), and very low (0%) likelihood of successful withdrawal. Conclusion: When conducted at late timepoints after transplantation, immunosuppression withdrawal is successful in a high proportion of carefully selected liver recipients. A combination of clinical parameters could be useful to predict the success of this strategy. Additional prospective studies are now needed to confirm these results and to validate clinically applicable diagnostic biomarkers. (Hepatology 2013;58:1824–1835)