Potential conflict of interest: Nothing to report.
Autoimmune, Cholestatic and Biliary Disease
Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice
Article first published online: 6 SEP 2013
Copyright © 2013 The Authors. HEPATOLOGY published by Wiley on behalf of the American Association for the Study of Liver Diseases.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Volume 58, Issue 4, pages 1401–1412, October 2013
How to Cite
Firrincieli, D., Zúñiga, S., Rey, C., Wendum, D., Lasnier, E., Rainteau, D., Braescu, T., Falguières, T., Boissan, M., Cadoret, A., Housset, C. and Chignard, N. (2013), Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice. Hepatology, 58: 1401–1412. doi: 10.1002/hep.26453
Silvia Zúñiga is currently affiliated with the Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Supported by the French Association for the Study of the Liver (AFEF), by “Association pour la lutte contre les maladies inflammatoires du foie et des voies biliaires” (ALBI), by “Fond CSP Vaincre la Cholangite Sclérosante Primitive,” and by the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-F2-2009-241762 for the project FLIP. S.Z. was recipient of a fellowship BECAS CHILE from Conicyt. T.F. was recipient of fellowships from INSERM and Fondation pour la Recherche Médicale (FRM).
- Issue published online: 1 OCT 2013
- Article first published online: 6 SEP 2013
- Accepted manuscript online: 20 MAY 2013 03:51PM EST
- Manuscript Accepted: 7 APR 2013
- Manuscript Revised: 5 APR 2013
- Manuscript Received: 31 OCT 2012
- French Association for the Study of the Liver (AFEF)
- “Association pour la lutte contre les maladies inflammatoires du foie et des voies biliaires” (ALBI)
- “Fond CSP Vaincre la Cholangite Sclérosante Primitive,”
- European Union Seventh Framework Programme . Grant Numbers: FP7/2007-2013 , HEALTH-F2-2009-241762
- BECAS CHILE from Conicyt
- Fondation pour la Recherche Médicale (FRM)
Additional Supporting Information may be found in the online version of this article.
|hep26453-sup-0001-suppfig1.tif||244K||Supporting Figure 1. Hepatic biochemistry of wild-type BDL mice treated with 1α-hydroxyvitamin D3.|
|hep26453-sup-0002-suppfig2.tif||264K||Supporting Figure 2. Adaptive changes in bile acid metabolism and transport in Vdr-/- mice after BDL.|
|hep26453-sup-0003-suppfig3.tif||246K||Supporting Figure 3. Hepatic bile acid pool composition of Vdr-/- and wild-type BDL mice.|
|hep26453-sup-0004-suppfig4.tif||240K||Supporting Figure 4. Hepatic biochemistry of wild-type BDL mice under chow or rescue diet.|
|hep26453-sup-0005-supptab1.docx||17K||Supporting Table 1: Primary antibodies used for immunodetection|
|hep26453-sup-0006-supptab2.docx||17K||Supporting Table 2: Primers used for qPCR|
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