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Additional Supporting Information may be found in the online version of this article.

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hep26469-sup-0001-suppfig1.tif14789KSupporting Fig. 1. Flow cytometric analysis for CD49d+ monocytic myeloid derived supressor cells (MDSCs). Representative dot plots and histograms showing that most of the CD11b+Gr-1dim cells are CD49d+ (upper panel) at 8 h after Con A administration. CD49d+ monocytic MDSCs were gated from mononuclear cells using FSC/SSC dot plots (lower panel).
hep26469-sup-0002-suppfig2.tif2325KSupporting Fig. 2. Effect of anti-α4 integrin or VAP-1 on serum alanine aminotransferase (ALT) and lung myeloperoxidase (MPO) level. 100 μl of sterile saline (UT), 100 µg of anti-α4 integrin (clone PS/2) or cocktail of 7-88 and 7-106 (50 µg each) were intravenously injected. At 8.5 h after injection, serum and lung tissue were collected for the measurement of ALT and MPO activity, respectively (n = 3-4 per group).
hep26469-sup-0003-suppfig3.tif847KSupporting Fig. 3. Effects of anti-α4 integrin and anti-VAP-1 on the NK, NKT and CD3 cell recruitment. Con A (15 mg/kg) was administered at 8 h prior to liver isolation and NK (CD3DX5+), NKT (CD3+DX5+) and CD3 (CD3+DX5) lymphocytes (B) were counted by flow cytometric analysis (n = 3-6 per group).
hep26469-sup-0004-suppfig4.tif10154KSupporting Fig. 4. Neutrophil influx into lungs in response to Con A (15 mg/kg) in mice treated with vehicle, anti-α4 integrin or anti-VAP-1 (n = 4-6 per group; **P < 0.01 versus vehicle-treated group by by two-way ANOVA with Bonferroni's correction). MPO, myeloperoxidase.
hep26469-sup-0005-suppvideo1.avi3886KSupporting Information Video 1
hep26469-sup-0006-suppvideo2.avi6132KSupporting Information Video 2
hep26469-sup-0007-suppvideo3.avi1078KSupporting Information Video 3
hep26469-sup-0008-suppvideo4.avi756KSupporting Information Video 4
hep26469-sup-0009-suppinfo.doc38KSupporting Information

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